Direct proline-catalyzed asymmetric α-aminoxylation of aldehydes and ketones

Yujiro Hayashi, Junichiro Yamaguchi, Tatsunobu Sumiya, Kazuhiro Hibino, Mitsuru Shoji

研究成果: Article査読

144 被引用数 (Scopus)

抄録

The direct proline-catalyzed asymmetric α-aminoxylation of aldehydes and ketones has been developed using nitrosobenzene as an oxygen source, affording α-anilinoxy-aldehydes and -ketones with excellent enantioselectivity. Reaction conditions have been optimized, and low temperature (-20 °C) was found to be a key for the successful α-aminoxylation of aldehydes, while slow addition of nitrosobenzene is essential for that of ketones. The scope of the reaction is presented.

本文言語English
ページ(範囲)5966-5973
ページ数8
ジャーナルJournal of Organic Chemistry
69
18
DOI
出版ステータスPublished - 2004 9 3

ASJC Scopus subject areas

  • 有機化学

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