Direct reprogramming of terminally differentiated B cells into erythroid lineage

Ken Sadahira, Yumi Fukuchi, Hiroyoshi Kunimono, Masatoshi Sakurai, Yasuo Ikeda, Shinichiro Okamoto, Hideaki Nakajima

研究成果: Article

5 引用 (Scopus)

抜粋

Hematopoietic progenitors have been shown to retain plasticity and switch lineages by appropriate stimuli. However, mature blood cells hardly showed such differentiation plasticity. In this paper, we tried to reprogram mature B cells into erythroid lineage by expressing various hematopoietic transcription factors. Among various factors, GATA-1, SCL together with CCAAT/enhancer binding protein (C/EBP) α turned out to be a minimal set of factors that efficiently reprogrammed terminally differentiated mature B cells into erythroid lineage, as evidenced by colony forming assays and erythroid-specific gene expressions. This study sets an avenue to generate autologous erythrocytes from peripheral B cells.

元の言語English
ページ(範囲)3645-3652
ページ数8
ジャーナルFEBS Letters
586
発行部数20
DOI
出版物ステータスPublished - 2012 10 19

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

フィンガープリント Direct reprogramming of terminally differentiated B cells into erythroid lineage' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Sadahira, K., Fukuchi, Y., Kunimono, H., Sakurai, M., Ikeda, Y., Okamoto, S., & Nakajima, H. (2012). Direct reprogramming of terminally differentiated B cells into erythroid lineage. FEBS Letters, 586(20), 3645-3652. https://doi.org/10.1016/j.febslet.2012.08.019