Discontinuation of living donor liver transplantation for PSC due to histological abnormalities in intraoperative donor liver biopsy

Y. Hasegawa, S. Kawachi, M. Shimazu, K. Hoshino, M. Tanabe, Y. Fuchimoto, H. Obara, M. Shinoda, H. Shimizu, Y. Yamada, T. Akatsu, R. Irie, M. Sakamoto, Y. Morikawa, M. Kitajima

研究成果: Article査読

12 被引用数 (Scopus)

抄録

Liver transplantation is the only curative treatment known to date for end-stage liver disease occurring as a result of primary sclerosing cholangitis (PSC). Here, we report a case in which living donor liver transplantation (LDLT) for PSC was cancelled because of histological abnormalities in intraoperative biopsy of the donor liver. The donor was the mother of the recipient, and her preoperative evaluation revealed no abnormalities. In the donor operation, the donor liver biopsy revealed expansion of the portal zone with lymphocytic infiltration and dense concentric fibrosis developed around a bile duct. These histological findings were identical to those of early-stage PSC; therefore, the LDLT was called off. The experience in this case suggests that preoperative liver biopsy may be useful to exclude first-degree relative donors with potential PSC prior to LDLT for PSC.

本文言語English
ページ(範囲)2204-2207
ページ数4
ジャーナルAmerican Journal of Transplantation
7
9
DOI
出版ステータスPublished - 2007 9

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 移植
  • 薬理学(医学)

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