Discontinuation of tyrosine kinase inhibitors in pediatric chronic myeloid leukemia

Haruko Shima, Akiko Kada, Akihiko Tanizawa, Iori Sato, Chikako Tono, Masaki Ito, Yuki Yuza, Akihiro Watanabe, Kiyoko Kamibeppu, Hideko Uryu, Katsuyoshi Koh, Chihaya Imai, Nao Yoshida, Yuhki Koga, Naoto Fujita, Akiko M. Saito, Souichi Adachi, Eiichi Ishii, Hiroyuki Shimada

研究成果: Article査読

1 被引用数 (Scopus)


Background: The feasibility of tyrosine kinase inhibitor (TKI) discontinuation in pediatric chronic myeloid leukemia (CML) remains to be fully elucidated. Procedures: TKI was prospectively discontinued in patients who were diagnosed with CML at <20 years of age, treated with TKI for ≥3 years, and sustained molecular response 4.0 (MR4.0) for ≥2 years. Molecular relapse was defined as a single loss of major molecular response (MMR) (BCR-ABL1IS >0.1%). Relapsed patients resumed the same TKI therapy administered before discontinuation. Results: Twenty-two patients with chronic-phase CML were enrolled, and the median ages at diagnosis and at TKI discontinuation were 9 (range: 1–14) years and 16 (5–26) years, respectively. The median follow-up time after TKI discontinuation was 37 months (range: 24–41 months). The median duration of TKI treatment before discontinuation was 100 (42–178) months, and that of MR4.0 was 53.5 (25–148) months. The treatment-free remission (TFR) rate at 12 months was 50.0% (90% confidence interval: 31.7%–65.8%). Eleven patients experienced loss of MMR within 4 months after TKI discontinuation and resumed TKI as originally prescribed. No progression was observed, and all 11 patients regained MR4.0 after TKI resumption. No patient had a withdrawal syndrome. The quality-of-life analysis suggested that successful TFR may improve academic performance in some patients. In patients who discontinued TKI therapy before puberty, the possibility of improvement in growth velocity upon TKI discontinuation was observed. Conclusions: TKI could be discontinued safely in patients with pediatric CML showing a sustained deep MR.

ジャーナルPediatric Blood and Cancer
出版ステータスPublished - 2022 8月

ASJC Scopus subject areas

  • 小児科学、周産期医学および子どもの健康
  • 血液学
  • 腫瘍学


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