Discovery, development, and testing of substrates and inhibitors of pp60c-SRC

Raymond J.A. Budde, John S. Mcmurray, Hideyuki Saya, Gary E. Gallick, Victor A. Levin

研究成果: Article査読

抄録

Currently, there are no specific protein tyrosine kinase inhibitors available. This review summarizes our efforts to develop an active-site-directed inhibitor of pp60c-srv Initial efforts are directed at determining substrate specificity with synthetic peptides and at developing a biological system to test the potential of pp60c-src inhibitors to effectively inhibit the growth of pp60c-src activated cell lines. To meet these goals, we have developed new methods for purifying recombinant pp60C-SRC, assaying tyrosine kinase activity, synthesizing cyclic peptides, and generating random peptide libraries. In addition, we discuss the generation of potential artifacts while using polyhydroxy aromatic compounds as tyrosine kinase inhibitors.

本文言語English
ページ(範囲)27-34
ページ数8
ジャーナルPharmaceutical Biology
33
S1
DOI
出版ステータスPublished - 1995
外部発表はい

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine

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