Disseminated histoplasmosis from a calcified lung nodule after long-term corticosteroid therapy in an elderly Japanese patient: A case report

Keigo Kobayashi, Takanori Asakura, Ichiro Kawada, Hanako Hasegawa, Shotaro Chubachi, Kentaro Ohara, Junko Kuramoto, Hiroaki Sugiura, Seitaro Fujishima, Satoshi Iwata, Takashi Umeyama, Harutaka Katano, Yoshifumi Uwamino, Yoshitsugu Miyazaki, Katsuhiko Kamei, Naoki Hasegawa, Tomoko Betsuyaku

研究成果: Article

抄録

RATIONALE: Histoplasmosis occurs most commonly in Northern and Central America and Southeast Asia. Increased international travel in Japan has led to a few annual reports of imported histoplasmosis. Healed sites of histoplasmosis lung infection may remain as nodules and are often accompanied by calcification. Previous studies in endemic areas supported the hypothesis that new infection/reinfection, rather than reactivation, is the main etiology of symptomatic histoplasmosis. No previous reports have presented clinical evidence of reactivation. PATIENT CONCERNS: An 83-year-old Japanese man was hospitalized with general fatigue and high fever. He had been treated with prednisolone at 13 mg/d for 7 years because of an eczematous skin disease. He had a history of travel to Los Angeles, Egypt, and Malaysia 10 to 15 years prior to admission. Five years earlier, computed tomography (CT) identified a solitary calcified nodule in the left lingual lung segment. The nodule size remained unchanged throughout a 5-year observation period. Upon admission, his respiratory condition remained stable while breathing room air. CT revealed small, randomly distributed nodular shadows in the bilateral lungs, in addition to the solitary nodule. DIAGNOSIS: Disseminated histoplasmosis, based on fungal staining and cultures of autopsy specimens. INTERVENTIONS: The patient's fever continued despite several days of treatment with meropenem, minocycline, and micafungin. Although he refused bone marrow aspiration, isoniazid, rifampicin, ethambutol, and prednisolone were administered for a tentative diagnosis of miliary tuberculosis. OUTCOMES: His fever persisted, and a laboratory examination indicated severe thrombocytopenia with disseminated intravascular coagulation. He died on day 43 postadmission. During autopsy, the fungal burden was noted to be higher in the calcified nodule than in the disseminated nodules of the lung, suggesting a pathogenesis involving endogenous reactivation of the nodule and subsequent hematogenous and lymphatic spread. LESSONS: Physicians should consider histoplasmosis in patients with calcified nodules because the infection may reactivate during long-term corticosteroid therapy.

元の言語English
ページ(範囲)e15264
ジャーナルMedicine
98
発行部数17
DOI
出版物ステータスPublished - 2019 4 1

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Histoplasmosis
Adrenal Cortex Hormones
Lung
Fever
meropenem
Prednisolone
Eczematous Skin Diseases
Autopsy
Therapeutics
Infection
Tomography
Central Asia
Miliary Tuberculosis
Central America
Annual Reports
Ethambutol
Southeastern Asia
Minocycline
Los Angeles
Disseminated Intravascular Coagulation

ASJC Scopus subject areas

  • Medicine(all)

これを引用

Disseminated histoplasmosis from a calcified lung nodule after long-term corticosteroid therapy in an elderly Japanese patient : A case report. / Kobayashi, Keigo; Asakura, Takanori; Kawada, Ichiro; Hasegawa, Hanako; Chubachi, Shotaro; Ohara, Kentaro; Kuramoto, Junko; Sugiura, Hiroaki; Fujishima, Seitaro; Iwata, Satoshi; Umeyama, Takashi; Katano, Harutaka; Uwamino, Yoshifumi; Miyazaki, Yoshitsugu; Kamei, Katsuhiko; Hasegawa, Naoki; Betsuyaku, Tomoko.

:: Medicine, 巻 98, 番号 17, 01.04.2019, p. e15264.

研究成果: Article

Kobayashi, K, Asakura, T, Kawada, I, Hasegawa, H, Chubachi, S, Ohara, K, Kuramoto, J, Sugiura, H, Fujishima, S, Iwata, S, Umeyama, T, Katano, H, Uwamino, Y, Miyazaki, Y, Kamei, K, Hasegawa, N & Betsuyaku, T 2019, 'Disseminated histoplasmosis from a calcified lung nodule after long-term corticosteroid therapy in an elderly Japanese patient: A case report', Medicine, 巻. 98, 番号 17, pp. e15264. https://doi.org/10.1097/MD.0000000000015264
Kobayashi, Keigo ; Asakura, Takanori ; Kawada, Ichiro ; Hasegawa, Hanako ; Chubachi, Shotaro ; Ohara, Kentaro ; Kuramoto, Junko ; Sugiura, Hiroaki ; Fujishima, Seitaro ; Iwata, Satoshi ; Umeyama, Takashi ; Katano, Harutaka ; Uwamino, Yoshifumi ; Miyazaki, Yoshitsugu ; Kamei, Katsuhiko ; Hasegawa, Naoki ; Betsuyaku, Tomoko. / Disseminated histoplasmosis from a calcified lung nodule after long-term corticosteroid therapy in an elderly Japanese patient : A case report. :: Medicine. 2019 ; 巻 98, 番号 17. pp. e15264.
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abstract = "RATIONALE: Histoplasmosis occurs most commonly in Northern and Central America and Southeast Asia. Increased international travel in Japan has led to a few annual reports of imported histoplasmosis. Healed sites of histoplasmosis lung infection may remain as nodules and are often accompanied by calcification. Previous studies in endemic areas supported the hypothesis that new infection/reinfection, rather than reactivation, is the main etiology of symptomatic histoplasmosis. No previous reports have presented clinical evidence of reactivation. PATIENT CONCERNS: An 83-year-old Japanese man was hospitalized with general fatigue and high fever. He had been treated with prednisolone at 13 mg/d for 7 years because of an eczematous skin disease. He had a history of travel to Los Angeles, Egypt, and Malaysia 10 to 15 years prior to admission. Five years earlier, computed tomography (CT) identified a solitary calcified nodule in the left lingual lung segment. The nodule size remained unchanged throughout a 5-year observation period. Upon admission, his respiratory condition remained stable while breathing room air. CT revealed small, randomly distributed nodular shadows in the bilateral lungs, in addition to the solitary nodule. DIAGNOSIS: Disseminated histoplasmosis, based on fungal staining and cultures of autopsy specimens. INTERVENTIONS: The patient's fever continued despite several days of treatment with meropenem, minocycline, and micafungin. Although he refused bone marrow aspiration, isoniazid, rifampicin, ethambutol, and prednisolone were administered for a tentative diagnosis of miliary tuberculosis. OUTCOMES: His fever persisted, and a laboratory examination indicated severe thrombocytopenia with disseminated intravascular coagulation. He died on day 43 postadmission. During autopsy, the fungal burden was noted to be higher in the calcified nodule than in the disseminated nodules of the lung, suggesting a pathogenesis involving endogenous reactivation of the nodule and subsequent hematogenous and lymphatic spread. LESSONS: Physicians should consider histoplasmosis in patients with calcified nodules because the infection may reactivate during long-term corticosteroid therapy.",
author = "Keigo Kobayashi and Takanori Asakura and Ichiro Kawada and Hanako Hasegawa and Shotaro Chubachi and Kentaro Ohara and Junko Kuramoto and Hiroaki Sugiura and Seitaro Fujishima and Satoshi Iwata and Takashi Umeyama and Harutaka Katano and Yoshifumi Uwamino and Yoshitsugu Miyazaki and Katsuhiko Kamei and Naoki Hasegawa and Tomoko Betsuyaku",
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T1 - Disseminated histoplasmosis from a calcified lung nodule after long-term corticosteroid therapy in an elderly Japanese patient

T2 - A case report

AU - Kobayashi, Keigo

AU - Asakura, Takanori

AU - Kawada, Ichiro

AU - Hasegawa, Hanako

AU - Chubachi, Shotaro

AU - Ohara, Kentaro

AU - Kuramoto, Junko

AU - Sugiura, Hiroaki

AU - Fujishima, Seitaro

AU - Iwata, Satoshi

AU - Umeyama, Takashi

AU - Katano, Harutaka

AU - Uwamino, Yoshifumi

AU - Miyazaki, Yoshitsugu

AU - Kamei, Katsuhiko

AU - Hasegawa, Naoki

AU - Betsuyaku, Tomoko

PY - 2019/4/1

Y1 - 2019/4/1

N2 - RATIONALE: Histoplasmosis occurs most commonly in Northern and Central America and Southeast Asia. Increased international travel in Japan has led to a few annual reports of imported histoplasmosis. Healed sites of histoplasmosis lung infection may remain as nodules and are often accompanied by calcification. Previous studies in endemic areas supported the hypothesis that new infection/reinfection, rather than reactivation, is the main etiology of symptomatic histoplasmosis. No previous reports have presented clinical evidence of reactivation. PATIENT CONCERNS: An 83-year-old Japanese man was hospitalized with general fatigue and high fever. He had been treated with prednisolone at 13 mg/d for 7 years because of an eczematous skin disease. He had a history of travel to Los Angeles, Egypt, and Malaysia 10 to 15 years prior to admission. Five years earlier, computed tomography (CT) identified a solitary calcified nodule in the left lingual lung segment. The nodule size remained unchanged throughout a 5-year observation period. Upon admission, his respiratory condition remained stable while breathing room air. CT revealed small, randomly distributed nodular shadows in the bilateral lungs, in addition to the solitary nodule. DIAGNOSIS: Disseminated histoplasmosis, based on fungal staining and cultures of autopsy specimens. INTERVENTIONS: The patient's fever continued despite several days of treatment with meropenem, minocycline, and micafungin. Although he refused bone marrow aspiration, isoniazid, rifampicin, ethambutol, and prednisolone were administered for a tentative diagnosis of miliary tuberculosis. OUTCOMES: His fever persisted, and a laboratory examination indicated severe thrombocytopenia with disseminated intravascular coagulation. He died on day 43 postadmission. During autopsy, the fungal burden was noted to be higher in the calcified nodule than in the disseminated nodules of the lung, suggesting a pathogenesis involving endogenous reactivation of the nodule and subsequent hematogenous and lymphatic spread. LESSONS: Physicians should consider histoplasmosis in patients with calcified nodules because the infection may reactivate during long-term corticosteroid therapy.

AB - RATIONALE: Histoplasmosis occurs most commonly in Northern and Central America and Southeast Asia. Increased international travel in Japan has led to a few annual reports of imported histoplasmosis. Healed sites of histoplasmosis lung infection may remain as nodules and are often accompanied by calcification. Previous studies in endemic areas supported the hypothesis that new infection/reinfection, rather than reactivation, is the main etiology of symptomatic histoplasmosis. No previous reports have presented clinical evidence of reactivation. PATIENT CONCERNS: An 83-year-old Japanese man was hospitalized with general fatigue and high fever. He had been treated with prednisolone at 13 mg/d for 7 years because of an eczematous skin disease. He had a history of travel to Los Angeles, Egypt, and Malaysia 10 to 15 years prior to admission. Five years earlier, computed tomography (CT) identified a solitary calcified nodule in the left lingual lung segment. The nodule size remained unchanged throughout a 5-year observation period. Upon admission, his respiratory condition remained stable while breathing room air. CT revealed small, randomly distributed nodular shadows in the bilateral lungs, in addition to the solitary nodule. DIAGNOSIS: Disseminated histoplasmosis, based on fungal staining and cultures of autopsy specimens. INTERVENTIONS: The patient's fever continued despite several days of treatment with meropenem, minocycline, and micafungin. Although he refused bone marrow aspiration, isoniazid, rifampicin, ethambutol, and prednisolone were administered for a tentative diagnosis of miliary tuberculosis. OUTCOMES: His fever persisted, and a laboratory examination indicated severe thrombocytopenia with disseminated intravascular coagulation. He died on day 43 postadmission. During autopsy, the fungal burden was noted to be higher in the calcified nodule than in the disseminated nodules of the lung, suggesting a pathogenesis involving endogenous reactivation of the nodule and subsequent hematogenous and lymphatic spread. LESSONS: Physicians should consider histoplasmosis in patients with calcified nodules because the infection may reactivate during long-term corticosteroid therapy.

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