Dissolution profile of 24 levofloxacin (100 mg) tablets

Kayoko Maezawa, Ryo Yajima, Tomoko Terajima, Junko Kizu, Seiji Hori

研究成果: Article

4 引用 (Scopus)


Although there are 23 generic levofloxacin (100 mg) tablets (LVFX tablets) and 1 brand name LVFX tablet (supply now discontinued) in Japan, there have been no reports that have evaluated and compared the dissolution profiles of LVFX tablets using the same dissolution method. We studied the dissolution profile of LVFX tablets by the Paddle method, a standard dissolution test method. Among 23 generic LVFX tablets, 2 LVFX tablets had lower dissolution rates and 14 had higher dissolution rates than the brand name LVFX tablet. It is suggested that LVFX tablets have different dissolution profiles, which could cause different pharmacokinetic profiles.

ジャーナルJournal of Infection and Chemotherapy
出版物ステータスPublished - 2013 10

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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