Distinct neuropsychological profiles of three major symptom dimensions in obsessive-compulsive disorder

Nobuhiko Hashimoto, Shutaro Nakaaki, Ichiro M. Omori, Junko Fujioi, Yuka Noguchi, Yoshie Murata, Junko Sato, Hiroshi Tatsumi, Katsuyoshi Torii, Masaru Mimura, Toshi A. Furukawa

研究成果: Article査読

47 被引用数 (Scopus)

抄録

Recent neuroimaging studies have suggested that different symptom dimensions are mediated by partially distinct neural systems in obsessive-compulsive disorder (OCD). However, the correlations between neuropsychological profiles and symptom dimensions in OCD are unknown. The aim of this study was to examine the extent to which OCD symptom dimensions were associated with episodic memory and attention and executive functions. The symptom dimensions of 63 patients with OCD were assessed using both the Padua Inventory and the Y-BOCS symptom checklist. Then, we administered the Logical Memory (LM) subset of the Wechsler Memory Scale-Revised (WMR-R) test and evaluated inhibition (Stroop test, Trail Making test) and cognitive flexibility (Digit Symbol test, Letter Fluency, and Category Fluency). While associations were observed between scores on the contamination/cleaning dimension and better performances on the LM and Trail Making tests, associations were also observed between scores on the aggressive/checking dimension and poorer performances on the Trail Making test. In addition, we found that scores on the symmetry/ordering dimension were associated with poorer performances on the LM and Trail Making tests. Our results support the hypothesis that different symptoms may represent distinct and partially overlapping neurocognitive networks in OCD patients.

本文言語English
ページ(範囲)166-173
ページ数8
ジャーナルPsychiatry Research
187
1-2
DOI
出版ステータスPublished - 2011 5月 15
外部発表はい

ASJC Scopus subject areas

  • 精神医学および精神衛生
  • 生物学的精神医学

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