Distinct patterns of lymphocyte count transition in lymphoproliferative disorder in patients with rheumatoid arthritis treated with methotrexate

Shuntaro Saito, Yuko Kaneko, Kunihiro Yamaoka, Michihide Tokuhira, Tsutomu Takeuchi

研究成果: Article査読

24 被引用数 (Scopus)

抄録

Objective. To clarify the characteristics of lymphoproliferative disorder (LPD) in patients with RA treated with MTX. Methods. Among 33 patients developing LPD during MTX treatment, 20 LPDs regressed spontaneously within 12 weeks after MTX cessation (regressive LPD), and 13 did not regress and most of them died or needed chemotherapy (persistent LPD). The control group consisted of 66 clinically matched MTX-treated RA patients without LPD. The clinical characteristics were compared between these three groups. Results. While no significant differences were found in clinical RA and LPD features among the three groups, the absolute lymphocyte number of the two LPD groups at LPD diagnosis was significantly lower than the control group (497/μl in the regressive vs 680/μl in the persistent vs 1400/μl in the control, P<0.05). After MTX withdrawal, the lymphocyte number in the regressive group rapidly recovered to 1214/μl (P<0.01) by week 2 and was thereafter maintained at an equivalent level to the control group. In contrast, lymphocyte level in the persistent group did not show significant increase throughout 12 weeks (620/μl at week 2, P = 0.57). Changes in lymphocyte number following MTX withdrawal clearly distinguished the regressive LPD from the persistent LPD. Conclusion. A significant decrease in lymphocyte count at the LPD diagnosis and its restoration after MTX withdrawal were markedly associated with spontaneous regression of LPD developing during MTX treatment.

本文言語English
論文番号kex002
ページ(範囲)940-946
ページ数7
ジャーナルRheumatology (United Kingdom)
56
6
DOI
出版ステータスPublished - 2017 6 1

ASJC Scopus subject areas

  • リウマチ学
  • 薬理学(医学)

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