Distribution of the high-affinity choline transporter in the human and macaque monkey spinal cord

Yasushi Kobayashi, Takashi Okuda, Yasunori Fujioka, George Matsumura, Yu Nishimura, Tatsuya Haga

研究成果: Article査読

41 被引用数 (Scopus)

抄録

The distribution of the high-affinity choline transporter (CHT) was determined in the human and macaque monkey spinal cord using in situ hybridization histochemistry and immunohistochemistry. Signals for CHT mRNA were observed in somatic motor neurons, sympathetic preganglionic neurons, and neurons in the medial part of lamina VII. The mRNA for CHT was co-localized in single neurons with the mRNAs for vesicular acetylcholine transporter and cholineacetyltransferase. These same cholinergic neuronal groups were labeled by immunohistochemistry for human CHT. Of somatic motor neurons, smaller cell bodies of γ-motor neurons were labeled very intensely, whereas larger cell bodies of α-motor neurons showed various degrees of labeling from weak to moderately intense. Human CHT is thus a novel cholinergic marker, which not only labels cholinergic neurons, but also reveals their heterogeneity.

本文言語English
ページ(範囲)25-28
ページ数4
ジャーナルNeuroscience Letters
317
1
DOI
出版ステータスPublished - 2002 1 4
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)

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