Divergent synthesis of pseudoenantiomers for ABC-ring moiety of steroids

Miyu Furuta, Kengo Hanaya, Takeshi Sugai, Mitsuru Shoji

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Steroid family has various bioactivities and characteristic polycyclic structure. Although several synthetic methods have been reported, more efficient way is desired for medicinal chemistry. In this Letter, we synthesized pseudoenantiomers of tricyclic enones toward both enantiomers for ABC-ring moiety of steroids utilizing d-mannitol as a chiral source. The key steps are radical domino cyclization of polyalkenyl-β-keto ester into tricyclic keto ester and subsequent dealkoxycarbonylation.

本文言語English
ページ(範囲)3189-3191
ページ数3
ジャーナルTetrahedron Letters
55
20
DOI
出版ステータスPublished - 2014 5 14

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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