@article{46a62288e4f24b7f8baee8a792ad6041,
title = "Divergent synthesis of pseudoenantiomers for ABC-ring moiety of steroids",
abstract = "Steroid family has various bioactivities and characteristic polycyclic structure. Although several synthetic methods have been reported, more efficient way is desired for medicinal chemistry. In this Letter, we synthesized pseudoenantiomers of tricyclic enones toward both enantiomers for ABC-ring moiety of steroids utilizing d-mannitol as a chiral source. The key steps are radical domino cyclization of polyalkenyl-β-keto ester into tricyclic keto ester and subsequent dealkoxycarbonylation.",
keywords = "Dealkoxycarbonylation, Domino reaction, Radical cyclization, Steroid, β-Keto ester",
author = "Miyu Furuta and Kengo Hanaya and Takeshi Sugai and Mitsuru Shoji",
note = "Funding Information: This work was supported by Platform for Drug Discovery, Informatics, and Structural Life Science from the Ministry of Education, Culture, Sports, Science, and Technology , Japan. We also thank Keio University Doctorate Student Grant-in-Aid Program 2012 (M.F.). ",
year = "2014",
month = may,
day = "14",
doi = "10.1016/j.tetlet.2014.04.018",
language = "English",
volume = "55",
pages = "3189--3191",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "20",
}