DNA degradation by the copper(II) complex with tripodal-ligands containing peptide group

Teruyuki Kobayashi, Takashi Okuno, Toshio Suzuki, Mami Kunita, Shigeru Ohba, Yuzo Nishida

研究成果: Article査読

27 被引用数 (Scopus)

抄録

Copper-based transition metal complexes which perform single-strand scission of DNA in a site-specific manner have been designed. The complexes Cu(dpg)+ and Cu(dpgt)C1+ (H(dpg) and (dpgt) represent bis(2-pyridylmethyl) derivatives of glycylglycine and glycylglycylglycine, respectively), were prepared in this study and its crystal structures were determined. We have found that Cu(dpgt)C1+ and Cu(dpg)+ complexes convert supercoiled plasmid DNA into a mixture of nicked and linear forms in the presence of hydrogen peroxide, whereas related Cu(II) complexes, which lack a peptide group, produce complete degradation of DNA under the same experimental conditions.

本文言語English
ページ(範囲)1553-1559
ページ数7
ジャーナルPolyhedron
17
9
DOI
出版ステータスPublished - 1998 5月 10

ASJC Scopus subject areas

  • 物理化学および理論化学
  • 無機化学
  • 材料化学

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