DNA degradation by the copper(II) complex with tripodal-ligands containing peptide group

Teruyuki Kobayashi, Takashi Okuno, Toshio Suzuki, Mami Kunita, Shigeru Ohba, Yuzo Nishida

研究成果: Article

27 引用 (Scopus)

抄録

Copper-based transition metal complexes which perform single-strand scission of DNA in a site-specific manner have been designed. The complexes Cu(dpg)+ and Cu(dpgt)C1+ (H(dpg) and (dpgt) represent bis(2-pyridylmethyl) derivatives of glycylglycine and glycylglycylglycine, respectively), were prepared in this study and its crystal structures were determined. We have found that Cu(dpgt)C1+ and Cu(dpg)+ complexes convert supercoiled plasmid DNA into a mixture of nicked and linear forms in the presence of hydrogen peroxide, whereas related Cu(II) complexes, which lack a peptide group, produce complete degradation of DNA under the same experimental conditions.

元の言語English
ページ(範囲)1553-1559
ページ数7
ジャーナルPolyhedron
17
発行部数9
出版物ステータスPublished - 1998 5 10

Fingerprint

Peptides
peptides
Copper
DNA
deoxyribonucleic acid
Ligands
Glycylglycine
degradation
Superhelical DNA
Degradation
copper
ligands
Coordination Complexes
Hydrogen Peroxide
Plasmids
plasmids
Metal complexes
hydrogen peroxide
Hydrogen peroxide
strands

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry
  • Physical and Theoretical Chemistry
  • Materials Chemistry

これを引用

Kobayashi, T., Okuno, T., Suzuki, T., Kunita, M., Ohba, S., & Nishida, Y. (1998). DNA degradation by the copper(II) complex with tripodal-ligands containing peptide group. Polyhedron, 17(9), 1553-1559.

DNA degradation by the copper(II) complex with tripodal-ligands containing peptide group. / Kobayashi, Teruyuki; Okuno, Takashi; Suzuki, Toshio; Kunita, Mami; Ohba, Shigeru; Nishida, Yuzo.

:: Polyhedron, 巻 17, 番号 9, 10.05.1998, p. 1553-1559.

研究成果: Article

Kobayashi, T, Okuno, T, Suzuki, T, Kunita, M, Ohba, S & Nishida, Y 1998, 'DNA degradation by the copper(II) complex with tripodal-ligands containing peptide group', Polyhedron, 巻. 17, 番号 9, pp. 1553-1559.
Kobayashi T, Okuno T, Suzuki T, Kunita M, Ohba S, Nishida Y. DNA degradation by the copper(II) complex with tripodal-ligands containing peptide group. Polyhedron. 1998 5 10;17(9):1553-1559.
Kobayashi, Teruyuki ; Okuno, Takashi ; Suzuki, Toshio ; Kunita, Mami ; Ohba, Shigeru ; Nishida, Yuzo. / DNA degradation by the copper(II) complex with tripodal-ligands containing peptide group. :: Polyhedron. 1998 ; 巻 17, 番号 9. pp. 1553-1559.
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