DNA diagnosis of hydatidiform mole using the polymerase chain reaction

Ryuichi Fukuyama, Mizuho Takata, Jun Kudoh, Kosuke Sakai, Shozo Tamura, Nobuyoshi Shimizu

研究成果: Article

20 引用 (Scopus)

抜粋

We have used the polymerase chain reaction (PCR) technique for the diagnosis of hydatidiform mole, a trophoblastic disease. For this, we targeted the hypervariable 3′ flanking region of the APOB gene (APOB/ VNTR) because of its high heterozygosity index (0.61) in the Japanese population. We examined seven clinical cases which were tentatively diagnosed as hydatidiform moles. Five of these revealed DNA segments unique to the paternal APOB allele, allowing us to diagnose a complete mole. The PCR technique for targeting the APOB/VNTR appears useful for early diagnosis of hydatidiform mole.

元の言語English
ページ(範囲)216-218
ページ数3
ジャーナルHuman Genetics
87
発行部数2
DOI
出版物ステータスPublished - 1991 6 1

    フィンガープリント

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

これを引用

Fukuyama, R., Takata, M., Kudoh, J., Sakai, K., Tamura, S., & Shimizu, N. (1991). DNA diagnosis of hydatidiform mole using the polymerase chain reaction. Human Genetics, 87(2), 216-218. https://doi.org/10.1007/BF00204186