DNA diagnosis of hydatidiform mole using the polymerase chain reaction

Ryuichi Fukuyama, Mizuho Takata, Jun Kudoh, Kosuke Sakai, Shozo Tamura, Nobuyoshi Shimizu

研究成果: Article査読

21 被引用数 (Scopus)

抄録

We have used the polymerase chain reaction (PCR) technique for the diagnosis of hydatidiform mole, a trophoblastic disease. For this, we targeted the hypervariable 3′ flanking region of the APOB gene (APOB/ VNTR) because of its high heterozygosity index (0.61) in the Japanese population. We examined seven clinical cases which were tentatively diagnosed as hydatidiform moles. Five of these revealed DNA segments unique to the paternal APOB allele, allowing us to diagnose a complete mole. The PCR technique for targeting the APOB/VNTR appears useful for early diagnosis of hydatidiform mole.

本文言語English
ページ(範囲)216-218
ページ数3
ジャーナルHuman genetics
87
2
DOI
出版ステータスPublished - 1991 6月

ASJC Scopus subject areas

  • 遺伝学
  • 遺伝学(臨床)

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