Pharmacokinetic-pharmacodynamic(PK-PD) analysis is important in selecting the antimicrobial agent dosage for appropriate use. No information on the spread of dosage determination based on PK-PD analysis has, to our knowledge, been reported. We studied how the PK-PD concept spread in the clinical field. Among respondents, 55% of doctors knew of the PK-PD concept, which 66% evaluated as very useful. They determined the dosage of carbapenems (78% of doctors), aminoglycosides (77%), and injectable cephems (75%) based on the PK-PD concept. Of these doctors, however, 55% determined the dosage of quinolones based on this concept. We suggest that training in PK-PD analysis and dosage determination based on PK-PD is important and urgent in appropriate antimicrobial agent use.
|ジャーナル||Japanese Journal of Chemotherapy|
|出版物ステータス||Published - 2010 7|
ASJC Scopus subject areas
- Pharmacology (medical)