Do doctors know of and use PK-PD-based antimicrobial agent dosage?

Junko Kizu, Satoshi Iwata, Shinya Kusachi, Junko Sato, Yoshitake Sato, Mitsuru Sandoh, Hiroaki Takeda, Kazuhiro Tateda, Seiji Hori

研究成果: Article

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Pharmacokinetic-pharmacodynamic(PK-PD) analysis is important in selecting the antimicrobial agent dosage for appropriate use. No information on the spread of dosage determination based on PK-PD analysis has, to our knowledge, been reported. We studied how the PK-PD concept spread in the clinical field. Among respondents, 55% of doctors knew of the PK-PD concept, which 66% evaluated as very useful. They determined the dosage of carbapenems (78% of doctors), aminoglycosides (77%), and injectable cephems (75%) based on the PK-PD concept. Of these doctors, however, 55% determined the dosage of quinolones based on this concept. We suggest that training in PK-PD analysis and dosage determination based on PK-PD is important and urgent in appropriate antimicrobial agent use.

元の言語English
ページ(範囲)460-465
ページ数6
ジャーナルJapanese Journal of Chemotherapy
58
発行部数4
出版物ステータスPublished - 2010 7

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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    Kizu, J., Iwata, S., Kusachi, S., Sato, J., Sato, Y., Sandoh, M., Takeda, H., Tateda, K., & Hori, S. (2010). Do doctors know of and use PK-PD-based antimicrobial agent dosage? Japanese Journal of Chemotherapy, 58(4), 460-465.