Docetaxel enhances the cytotoxicity of anthracyclines by increasing intracellular drug accumulation

Tomohisa Egawa, Tetsuro Kubota, Akihiko Suto, Yoshihide Otani, Toshiharu Furukawa, Masahiko Watanabe, Koichiro Kumai, Masaki Kitajima

研究成果: Article

3 引用 (Scopus)

抄録

We assessed the combined antitumor activity of docetaxel and doxorubicin (DXR) and tetrahydropyranyladriamycin (THP) using the human breast carcinoma cell lines R-27 and MDA-MB-231. Synergistic antitumor activity was observed for both combined docetaxel and DXR, and docetaxel and THP against R-27 cells when contacted simultaneously. However, only additive effects were observed against MDA-MB-231 cells. Intracellular concentrations of DXR and THP in R-27 cells were significantly increased by docetaxel pretreatment, however, this increase was not observed in MDA-MB-231 cells, which exhibited only additive sensitivity to the treatment. Thus, docetaxel increased the antitumor activity of anthracyclines by increasing their intracellular concentrations.

元の言語English
ページ(範囲)777-781
ページ数5
ジャーナルOncology Reports
9
発行部数4
出版物ステータスPublished - 2002 7

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docetaxel
Anthracyclines
Doxorubicin
Pharmaceutical Preparations
Breast Neoplasms
Cell Line

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

これを引用

Egawa, T., Kubota, T., Suto, A., Otani, Y., Furukawa, T., Watanabe, M., ... Kitajima, M. (2002). Docetaxel enhances the cytotoxicity of anthracyclines by increasing intracellular drug accumulation. Oncology Reports, 9(4), 777-781.

Docetaxel enhances the cytotoxicity of anthracyclines by increasing intracellular drug accumulation. / Egawa, Tomohisa; Kubota, Tetsuro; Suto, Akihiko; Otani, Yoshihide; Furukawa, Toshiharu; Watanabe, Masahiko; Kumai, Koichiro; Kitajima, Masaki.

:: Oncology Reports, 巻 9, 番号 4, 07.2002, p. 777-781.

研究成果: Article

Egawa, T, Kubota, T, Suto, A, Otani, Y, Furukawa, T, Watanabe, M, Kumai, K & Kitajima, M 2002, 'Docetaxel enhances the cytotoxicity of anthracyclines by increasing intracellular drug accumulation', Oncology Reports, 巻. 9, 番号 4, pp. 777-781.
Egawa, Tomohisa ; Kubota, Tetsuro ; Suto, Akihiko ; Otani, Yoshihide ; Furukawa, Toshiharu ; Watanabe, Masahiko ; Kumai, Koichiro ; Kitajima, Masaki. / Docetaxel enhances the cytotoxicity of anthracyclines by increasing intracellular drug accumulation. :: Oncology Reports. 2002 ; 巻 9, 番号 4. pp. 777-781.
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AU - Egawa, Tomohisa

AU - Kubota, Tetsuro

AU - Suto, Akihiko

AU - Otani, Yoshihide

AU - Furukawa, Toshiharu

AU - Watanabe, Masahiko

AU - Kumai, Koichiro

AU - Kitajima, Masaki

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KW - Breast cancer

KW - Combination therapy

KW - Docetaxel

KW - Doxorubicin

KW - Intracellular concentration

KW - Synergism

KW - Tetrahydropyranyladriamycin

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