Docetaxel enhances the cytotoxicity of tetrahydropyranyladriamycin in a sequence-dependent manner

T. Egawa, T. Kubota, Toshiharu Furukawa, Y. Otani, M. Watanabe, T. Furukawa, K. Kumai, M. Kitajima

研究成果: Article

4 引用 (Scopus)

抄録

Background: Taxanes and anthracyclines are active against breast cancer. In this study we investigated the combined antitumor activity of these drugs, with particular regard to sequence-dependency. Materials and Methods: The combined antitumor activity of docetaxel and tetrahydropyranyladriamycin (THP) against two human breast cancer xenografts was assessed using an in vitro histoculture drug-response assay. The sequence-dependency of the combined cytotoxicity was evaluated by isobologram. Results: A synergistic antitumor activity of combined docetaxel + THP was exhibited against the R-27 xenograft when docetaxel was given first or simultaneously with THP. However, this synergism was diminished when THP was used before docetaxel. While an additive effect of combined docetaxel + THP was observed against MX-1 xenograft when docetaxel was given first or simultaneously with THP, this effect was not marked using the THP/docetaxel sequence. Conclusion: Docetaxel increased the antitumor activity of THP, but only when administered before or simultaneously with THP.

元の言語English
ページ(範囲)2597-2600
ページ数4
ジャーナルAnticancer Research
21
発行部数4 A
出版物ステータスPublished - 2001

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docetaxel
Heterografts
Breast Neoplasms
Taxoids
Anthracyclines
Antineoplastic Agents

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

これを引用

Egawa, T., Kubota, T., Furukawa, T., Otani, Y., Watanabe, M., Furukawa, T., ... Kitajima, M. (2001). Docetaxel enhances the cytotoxicity of tetrahydropyranyladriamycin in a sequence-dependent manner. Anticancer Research, 21(4 A), 2597-2600.

Docetaxel enhances the cytotoxicity of tetrahydropyranyladriamycin in a sequence-dependent manner. / Egawa, T.; Kubota, T.; Furukawa, Toshiharu; Otani, Y.; Watanabe, M.; Furukawa, T.; Kumai, K.; Kitajima, M.

:: Anticancer Research, 巻 21, 番号 4 A, 2001, p. 2597-2600.

研究成果: Article

Egawa, T, Kubota, T, Furukawa, T, Otani, Y, Watanabe, M, Furukawa, T, Kumai, K & Kitajima, M 2001, 'Docetaxel enhances the cytotoxicity of tetrahydropyranyladriamycin in a sequence-dependent manner', Anticancer Research, 巻. 21, 番号 4 A, pp. 2597-2600.
Egawa T, Kubota T, Furukawa T, Otani Y, Watanabe M, Furukawa T その他. Docetaxel enhances the cytotoxicity of tetrahydropyranyladriamycin in a sequence-dependent manner. Anticancer Research. 2001;21(4 A):2597-2600.
Egawa, T. ; Kubota, T. ; Furukawa, Toshiharu ; Otani, Y. ; Watanabe, M. ; Furukawa, T. ; Kumai, K. ; Kitajima, M. / Docetaxel enhances the cytotoxicity of tetrahydropyranyladriamycin in a sequence-dependent manner. :: Anticancer Research. 2001 ; 巻 21, 番号 4 A. pp. 2597-2600.
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abstract = "Background: Taxanes and anthracyclines are active against breast cancer. In this study we investigated the combined antitumor activity of these drugs, with particular regard to sequence-dependency. Materials and Methods: The combined antitumor activity of docetaxel and tetrahydropyranyladriamycin (THP) against two human breast cancer xenografts was assessed using an in vitro histoculture drug-response assay. The sequence-dependency of the combined cytotoxicity was evaluated by isobologram. Results: A synergistic antitumor activity of combined docetaxel + THP was exhibited against the R-27 xenograft when docetaxel was given first or simultaneously with THP. However, this synergism was diminished when THP was used before docetaxel. While an additive effect of combined docetaxel + THP was observed against MX-1 xenograft when docetaxel was given first or simultaneously with THP, this effect was not marked using the THP/docetaxel sequence. Conclusion: Docetaxel increased the antitumor activity of THP, but only when administered before or simultaneously with THP.",
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T1 - Docetaxel enhances the cytotoxicity of tetrahydropyranyladriamycin in a sequence-dependent manner

AU - Egawa, T.

AU - Kubota, T.

AU - Furukawa, Toshiharu

AU - Otani, Y.

AU - Watanabe, M.

AU - Furukawa, T.

AU - Kumai, K.

AU - Kitajima, M.

PY - 2001

Y1 - 2001

N2 - Background: Taxanes and anthracyclines are active against breast cancer. In this study we investigated the combined antitumor activity of these drugs, with particular regard to sequence-dependency. Materials and Methods: The combined antitumor activity of docetaxel and tetrahydropyranyladriamycin (THP) against two human breast cancer xenografts was assessed using an in vitro histoculture drug-response assay. The sequence-dependency of the combined cytotoxicity was evaluated by isobologram. Results: A synergistic antitumor activity of combined docetaxel + THP was exhibited against the R-27 xenograft when docetaxel was given first or simultaneously with THP. However, this synergism was diminished when THP was used before docetaxel. While an additive effect of combined docetaxel + THP was observed against MX-1 xenograft when docetaxel was given first or simultaneously with THP, this effect was not marked using the THP/docetaxel sequence. Conclusion: Docetaxel increased the antitumor activity of THP, but only when administered before or simultaneously with THP.

AB - Background: Taxanes and anthracyclines are active against breast cancer. In this study we investigated the combined antitumor activity of these drugs, with particular regard to sequence-dependency. Materials and Methods: The combined antitumor activity of docetaxel and tetrahydropyranyladriamycin (THP) against two human breast cancer xenografts was assessed using an in vitro histoculture drug-response assay. The sequence-dependency of the combined cytotoxicity was evaluated by isobologram. Results: A synergistic antitumor activity of combined docetaxel + THP was exhibited against the R-27 xenograft when docetaxel was given first or simultaneously with THP. However, this synergism was diminished when THP was used before docetaxel. While an additive effect of combined docetaxel + THP was observed against MX-1 xenograft when docetaxel was given first or simultaneously with THP, this effect was not marked using the THP/docetaxel sequence. Conclusion: Docetaxel increased the antitumor activity of THP, but only when administered before or simultaneously with THP.

KW - Breast cancer

KW - Combination therapy

KW - Docetaxel

KW - Synergism

KW - Tetrahydropyranyladriamycin

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