Dolabelides C and D, cytotoxic macrolides isolated from the sea hare Dolabella auricularia

Kiyotake Suenaga, Tomohiro Nagoya, Takunobu Shibata, Hideo Kigoshi, Kiyoyuki Yamada

研究成果: Article

33 引用 (Scopus)

抄録

Two new cytotoxic 24-membered macrolides, dolabelides C and D, were isolated from the Japanese sea hare Dolabella auricularia. Their gross structures were deduced by spectroscopic analysis including the 2D NMR technique, and their absolute stereochemistry was determined by means of chemical correlation with the known dolabelide A. Dolabelides C and D exhibited cytotoxicities against HeLa S3 cells with IC50 values of 1.9 and 1.5 μg/mL, respectively.

元の言語English
ページ(範囲)155-157
ページ数3
ジャーナルJournal of Natural Products
60
発行部数2
DOI
出版物ステータスPublished - 1997
外部発表Yes

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macrolides
Stereochemistry
Spectroscopic analysis
Macrolides
stereochemistry
Cytotoxicity
HeLa Cells
Oceans and Seas
Inhibitory Concentration 50
inhibitory concentration 50
cytotoxicity
Nuclear magnetic resonance
cells
methodology
dolabelide A
Dolabella auricularia
Anaspidea

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

これを引用

Dolabelides C and D, cytotoxic macrolides isolated from the sea hare Dolabella auricularia. / Suenaga, Kiyotake; Nagoya, Tomohiro; Shibata, Takunobu; Kigoshi, Hideo; Yamada, Kiyoyuki.

:: Journal of Natural Products, 巻 60, 番号 2, 1997, p. 155-157.

研究成果: Article

Suenaga, Kiyotake ; Nagoya, Tomohiro ; Shibata, Takunobu ; Kigoshi, Hideo ; Yamada, Kiyoyuki. / Dolabelides C and D, cytotoxic macrolides isolated from the sea hare Dolabella auricularia. :: Journal of Natural Products. 1997 ; 巻 60, 番号 2. pp. 155-157.
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