Dopamine D2/3 receptor availability in the striatum of antipsychotic-free older patients with schizophrenia-A [11C]-raclopride PET study

Shinichiro Nakajima, Fernando Caravaggio, David C. Mamo, Benoit H. Mulsant, Jun Ku Chung, Eric Plitman, Yusuke Iwata, Philip Gerretsen, Hiroyuki Uchida, Takefumi Suzuki, Wanna Mar, Alan A. Wilson, Sylvain Houle, Ariel Graff-Guerrero

研究成果: Article査読

15 被引用数 (Scopus)

抄録

Background: No study has examined dopamine D2/3 receptor (D2/3R) availability in antipsychotic-free older patients with schizophrenia. Methods: We included patients with schizophrenia 50years or older who were antipsychotic-free for at least 3months. We compared non-displaceable binding potential (BPND) of [11C]-raclopride in the caudate, putamen, ventral striatum, and globus pallidus between patients and age- and sex-matched healthy controls. Results: Ten patients participated (antipsychotic-naive=4). No differences in BPND were found between patients and controls in any ROIs (F(1, 72)=42, p=52). Conclusion: The preliminary results suggest no differences in D2/3R availability between antipsychotic-free older patients with schizophrenia and controls.

本文言語English
ページ(範囲)263-267
ページ数5
ジャーナルSchizophrenia Research
164
1-3
DOI
出版ステータスPublished - 2015 5月 1

ASJC Scopus subject areas

  • 精神医学および精神衛生
  • 生物学的精神医学

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