Dopamine Transporter Gene Polymorphism and Psychiatric Symptoms Seen in Schizophrenic Patients at Their First Episode

Toshiya Inada, Tetsuyoshi Sugita, Izumi Dobashi, Ataru Inagaki, Yoshie Kitao, Genichi Matsuda, Shingo Kato, Toshiya Takano, Gohei Yagi, Masahiro Asai

研究成果: Article査読

32 被引用数 (Scopus)

抄録

To investigate the possible role of the dopamine transporter (DAT) gene in determining the phenotype in human subjects, allele frequencies for the 40-bp variable number of tandem repeats (VNTR) polymorphism at this site were compared between 117 Japanese normal controls and 118 schizophrenic patients, including six subgroups: early-onset, those with a family history, and those suffering from one of the following psychiatric symptoms at their first episode: delusion and hallucination; disorganization; bizarre behavior; and negative symptoms. No significant differences were observed between the group as a whole or any subgroup of schizophrenic patients and controls. The results indicate that VNTR polymorphism in the DAT gene is unlikely to be a major contributor to any of the psychiatric parameters examined in the present population of schizophrenic subjects.

本文言語English
ページ(範囲)406-408
ページ数3
ジャーナルAmerican Journal of Medical Genetics - Seminars in Medical Genetics
67
4
DOI
出版ステータスPublished - 1996 7 26

ASJC Scopus subject areas

  • 遺伝学
  • 遺伝学(臨床)

フィンガープリント

「Dopamine Transporter Gene Polymorphism and Psychiatric Symptoms Seen in Schizophrenic Patients at Their First Episode」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル