Dose Distribution Analysis in Stereotactic Body Radiotherapy Using Dynamic Conformal Multiple Arc Therapy

Atsuya Takeda, Etsuo Kunieda, Naoko Sanuki, Toshio Ohashi, Yohei Oku, Yasunobu Sudo, Hideo Iwashita, Yoshikazu Ooka, Yosuke Aoki, Naoyuki Shigematsu, Atsushi Kubo

研究成果: Article査読

49 被引用数 (Scopus)

抄録

Purpose: We have used dynamic conformal multiple arc therapy (DCMAT) for stereotactic body radiotherapy (SBRT) since 2001. We investigated the consistency of DCMAT for SBRT using dose-volume histogram analysis. Methods and Materials: A total of 50 patients with peripheral lung tumors underwent SBRT. The median tumor diameter was 2.4 cm (range, 0.9-5.9). Treatment planning was performed using a superposition algorithm. The prescribed 50 Gy dose was divided into five fractions. The prescribed dose was defined as 80% of the maximal dose in the planning target volume (PTV), and the leaf margins were modified to ensure the PTV was included in the 80% isodose surface. The dose-volume histogram analysis was used to assess the PTV and normal lung volume. Results: The median dose covering 95% of the PTV was 50.27 Gy (range, 46.14-52.67), essentially consistent with the prescribed dose. The median homogeneity and conformity index was 1.41 (range, 1.31-1.53) and 1.73 (range, 1.41-2.21), respectively. The median volume of lung receiving ≥20 Gy (V20) was 4.2% (range, 1.4-10.2%). A linear correlation was found between the tumor diameter and V20, and an even stronger correlation was found between the PTV/(normal lung volume) and V20. The estimated V20 was 7.1% (range, 3.9-10.4%) for a 5-cm-diameter tumor, assumed to be the maximal size limitation for SBRT. Conclusion: SBRT with DCMAT achieved high conformity and delivered adequate doses within the PTV. The median dose covering 95% of the PTV was consistent with the prescribed dose. V20 can be estimated using the tumor diameter and normal lung volume. DCMAT was thus both a feasible and a reproducible method of SBRT delivery.

本文言語English
ページ(範囲)363-369
ページ数7
ジャーナルInternational Journal of Radiation Oncology Biology Physics
74
2
DOI
出版ステータスPublished - 2009 6 1

ASJC Scopus subject areas

  • 放射線
  • 腫瘍学
  • 放射線学、核医学およびイメージング
  • 癌研究

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