Double-phase helical CT of small renal parenchymal neoplasms: Correlation with pathologic findings and tumor angiogenesis

Masahiro Jinzaki, Akihiro Tanimoto, Makio Mukai, Eiji Ikeda, Seiji Kobayashi, Yuji Yuasa, Yoshiaki Narimatsu, Masaru Murai

研究成果: Article査読

270 被引用数 (Scopus)

抄録

Purpose: To correlate the enhancement pattern of double-phase helical computed tomography (CT) of small renal parenchymal neoplasms with pathologic findings and tumor angiogenesis, and evaluate whether the enhancement pattern would be useful in differentiating the histomorphologic types of small renal parenchymal neoplasms. Materials and Methods: Double-phase helical CT (5 mm slice) of the cortico-medullary phase (CMP) and late nephrographic phase (NP) was performed in 40 surgically resected renal neoplasms <3.5 cm. The patterns of CT attenuation value and homogeneity were correlated with the subtypes of neoplasms, microvessel density, and the existence of intratumoral necrosis or hemorrhage. Results: Clear cell renal cell carcinomas (RCC) (n = 29) showed a peak attenuation value in the CMP of >100 HU [Hounsfield units]. Chromophobe cell RCC (n = 2) showed a peak attenuation value in the CMP of <100 HU. Papillary RCC (n = 5) showed a gradual enhancement with the attenuation value in the CMP of <100 HU. However oncocytomas (n = 2) and metanephric adenomas (n = 2) also showed patterns similar to these subtypes of RCC. The degree of enhancement in the CMP correlated with microvessel density (r = 0.87). All tumors with an homogeneous enhancement pattern did not show necrosis or hemorrhage on histologic specimen. Conclusion: The enhancement pattern in double-phase helical CT was different among the subtypes of RCC, and correlated with microvessel density or the existence of intratumoral necrosis or hemorrhage. However it did not differentiate between RCC and other solid tumors.

本文言語English
ページ(範囲)835-842
ページ数8
ジャーナルJournal of Computer Assisted Tomography
24
6
DOI
出版ステータスPublished - 2000 12 1

ASJC Scopus subject areas

  • 放射線学、核医学およびイメージング

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