Drosophila big brain does not act as a water channel, but mediates cell adhesion

Kimiko Tatsumi, Shoji Tsuji, Hideki Miwa, Toshinori Morisaku, Mutsuo Nuriya, Minako Orihara, Kazunari Kaneko, Hideyuki Okano, Masato Yasui

研究成果: Article

22 引用 (Scopus)

抜粋

The neurogenic gene Drosophila big brain (bib) has a high sequence homology to aquaporin-4. However, its cellular functions in Drosophila neurogenesis have remained elusive. Here we investigated cell adhesion, and the ion and water permeability of Bib. The adhesive function was examined by a cell aggregation assay using L cells. Bib-transfected L cells formed aggregated clusters, while control-L cells remained as a single cell suspension. Ion permeation was not confirmed in L cells stably expressing Bib. When expressed in COS7 cells, Bib exhibited limited water permeability. This newly found cell adhesive function of Bib may be important for Drosophila neurogenesis.

元の言語English
ページ(範囲)2077-2082
ページ数6
ジャーナルFEBS Letters
583
発行部数12
DOI
出版物ステータスPublished - 2009 6 18

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ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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