Drosophila caspase transduces Shaggy/GSK-3β kinase activity in neural precursor development

Hirotaka Kanuka, Erina Kuranaga, Kiwamu Takemoto, Tetsuo Hiratou, Hideyuki Okano, Masayuki Miura

研究成果: Article査読

81 被引用数 (Scopus)

抄録

Caspases are well known for their role in the execution of apoptotic programs, in which they cleave specific target proteins, leading to the elimination of cells, and for their role in cytokine maturation. In this study, we identified a novel substrate, which, through cleavage by caspases, can regulate Drosophila neural precursor development. Shaggy (Sgg)46 protein, an isoform encoded by the sgg gene and essential for the negative regulation of Wingless signaling, is cleaved by the Dark-dependent caspase. This cleavage converts it to an active kinase, which contributes to the formation of neural precursor (sensory organ precursor (SOP)) cells. Our evidence suggests that caspase regulation of the wingless pathway is not associated with apoptotic cell death. These results imply a novel role for caspases in modulating cell signaling pathways through substrate cleavage in neural precursor development.

本文言語English
ページ(範囲)3793-3806
ページ数14
ジャーナルEMBO Journal
24
21
DOI
出版ステータスPublished - 2005 11月 2

ASJC Scopus subject areas

  • 神経科学(全般)
  • 分子生物学
  • 生化学、遺伝学、分子生物学(全般)
  • 免疫学および微生物学(全般)

フィンガープリント

「Drosophila caspase transduces Shaggy/GSK-3β kinase activity in neural precursor development」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル