Drug-carrying latices for prolonged release of drugs

H. Kawaguchi, S. Kataiwa, T. Mita, Y. Ohtsuka, T. Takeuchi, S. Kobayashi

研究成果: Article査読

3 被引用数 (Scopus)

抄録

Dichlorophene was used as a model drug. Drug-carrying latex particles were prepared by soap-free emulsion copolymerization of dichlorophene acrylate with some hydrophilic methacrylate comonomers. The comonomers used affected not only the structure and colloidal stability of particles, but also the drug-activity of particles. Preliminary study of the drug activity revealed that highly hydrophilic latex particles were very stable and too inactive to be engulfed by amoebae and kill them. On the contrary, less hydrophilic particles carrying a large amount of drug can be an effective device to release drugs at a moderate rate to fight against extracelluar targets such as parasites.

本文言語English
ページ(範囲)1167-1173
ページ数7
ジャーナルColloid & Polymer Science
268
12
DOI
出版ステータスPublished - 1990 12月 1

ASJC Scopus subject areas

  • 物理化学および理論化学
  • ポリマーおよびプラスチック
  • コロイド化学および表面化学
  • 材料化学

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