Drug-carrying latices for prolonged release of drugs

H. Kawaguchi, S. Kataiwa, T. Mita, Y. Ohtsuka, T. Takeuchi, S. Kobayashi

研究成果: Article

3 引用 (Scopus)

抄録

Dichlorophene was used as a model drug. Drug-carrying latex particles were prepared by soap-free emulsion copolymerization of dichlorophene acrylate with some hydrophilic methacrylate comonomers. The comonomers used affected not only the structure and colloidal stability of particles, but also the drug-activity of particles. Preliminary study of the drug activity revealed that highly hydrophilic latex particles were very stable and too inactive to be engulfed by amoebae and kill them. On the contrary, less hydrophilic particles carrying a large amount of drug can be an effective device to release drugs at a moderate rate to fight against extracelluar targets such as parasites.

元の言語English
ページ(範囲)1167-1173
ページ数7
ジャーナルColloid & Polymer Science
268
発行部数12
DOI
出版物ステータスPublished - 1990 12

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Latex
latex
Latexes
Particles (particulate matter)
drugs
Soaps (detergents)
Pharmaceutical Preparations
Copolymerization
Emulsions
amoeba
parasites
soaps
Methacrylates
copolymerization
acrylates
emulsions
Parasites

ASJC Scopus subject areas

  • Polymers and Plastics
  • Materials Chemistry
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

これを引用

Kawaguchi, H., Kataiwa, S., Mita, T., Ohtsuka, Y., Takeuchi, T., & Kobayashi, S. (1990). Drug-carrying latices for prolonged release of drugs. Colloid & Polymer Science, 268(12), 1167-1173. https://doi.org/10.1007/BF01410683

Drug-carrying latices for prolonged release of drugs. / Kawaguchi, H.; Kataiwa, S.; Mita, T.; Ohtsuka, Y.; Takeuchi, T.; Kobayashi, S.

:: Colloid & Polymer Science, 巻 268, 番号 12, 12.1990, p. 1167-1173.

研究成果: Article

Kawaguchi, H, Kataiwa, S, Mita, T, Ohtsuka, Y, Takeuchi, T & Kobayashi, S 1990, 'Drug-carrying latices for prolonged release of drugs', Colloid & Polymer Science, 巻. 268, 番号 12, pp. 1167-1173. https://doi.org/10.1007/BF01410683
Kawaguchi H, Kataiwa S, Mita T, Ohtsuka Y, Takeuchi T, Kobayashi S. Drug-carrying latices for prolonged release of drugs. Colloid & Polymer Science. 1990 12;268(12):1167-1173. https://doi.org/10.1007/BF01410683
Kawaguchi, H. ; Kataiwa, S. ; Mita, T. ; Ohtsuka, Y. ; Takeuchi, T. ; Kobayashi, S. / Drug-carrying latices for prolonged release of drugs. :: Colloid & Polymer Science. 1990 ; 巻 268, 番号 12. pp. 1167-1173.
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