One of the modern medicinal chemistry methods is kinetic target-guided synthesis, where fragment molecules are interacted with a target protein and those in close proximity on the protein spontaneously cross - link by forming a covalent bond. The reactions, which is applicable to the kinetic target-guided synthesis proceed in water and are required no additional reagent. Here, several examples of kinetic target - guided synthesis are described.
|ジャーナル||Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry|
|出版ステータス||Published - 2015|
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