Drug interaction between oral solution itraconazole and calcineurin inhibitors in allogeneic hematopoietic stem cell transplantation recipients: An association with bioavailability of oral solution itraconazole

Takehiko Mori, Yoshinobu Aisa, Jun Kato, Yukinori Nakamura, Yasuo Ikeda, Shinichiro Okamoto

研究成果: Article査読

21 被引用数 (Scopus)

抄録

To assess the drug interaction between oral solution itraconazole and calcineurin inhibitors, 10 recipients of allogeneic hematopoietic stem cell transplantation (HSCT), in whom oral solution itraconazole was started when they had been on a steady dose of calcineurin inhibitors (cyclosporine A or tacrolimus), were retrospectively evaluated. The concentration/dose [C/D; (ng/mL)/(mg/kg)] ratio of calcineurin inhibitors significantly increased after initiating oral solution itraconazole, and the increase at 7-10 days after initiating itraconazole was 93.7%, ranging from 37.3 to 328.2%. The plasma level of itraconazole/hydroxyitraconazole was significantly correlated with the increase in the C/D ratio of calcineurin inhibitors (correlation coefficient, 0.65; P < 0.05). These results suggest that oral solution itraconazole significantly interacts with calcineurin inhibitors with a wide interindividual variability in allogeneic HSCT recipients, which could partly be explained by the variable bioavailability of oral solution itraconazole.

本文言語English
ページ(範囲)103-107
ページ数5
ジャーナルInternational journal of hematology
90
1
DOI
出版ステータスPublished - 2009 7

ASJC Scopus subject areas

  • 血液学

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