Dual role of macrophage in tumor immunity

Ryota Tamura, Toshihide Tanaka, Yohei Yamamoto, Yasuharu Akasaki, Hikaru Sasaki

研究成果: Review article査読

48 被引用数 (Scopus)

抄録

Macrophages are significant in immune responses, assuming a defensive role. In contrast, macrophages often cause undesirable changes. These reactions are processes by which macrophages express different functional programs in response to microenvironmental signals, defined as M1/M2 polarization. Tumor immunity has been acknowledged for contributing to the elucidation of the mechanism and clinical application in cancer therapy. One of the mechanisms for the refractoriness to cancer immunotherapy is the production of inhibitory cytokines by tumor cells or macrophages. Therefore, therapeutic strategy targeting macrophage or macrophage-derived cytokines may be effective and attractive. This review aims to investigate macrophage-associated pathophysiology and biological behavior in cancers, especially related to microenvironment, such as hypoxia, and current topics regarding some therapies involving macrophages.

本文言語English
ページ(範囲)899-909
ページ数11
ジャーナルImmunotherapy
10
10
DOI
出版ステータスPublished - 2018 8

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学
  • 腫瘍学

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