Dynactin is essential for growth cone advance

Takako K. Abe, Takao Honda, Kohtaro Takei, Katsuhiko Mikoshiba, Diane Hoffman-Kim, Daniel G. Jay, Ryozo Kuwano

研究成果: Article査読

12 被引用数 (Scopus)

抄録

Dynactin is a multi-subunit complex that serves as a critical cofactor of the microtubule motor cytoplasmic dynein. We previously identified dynactin in the nerve growth cone. However, the function of dynactin in the growth cone is still unclear. Here we show that dynactin in the growth cone is required for constant forward movement of the growth cone. Chromophore-assisted laser inactivation (CALI) of dynamitin, a dynactin subunit, within the growth cone markedly decreases the rate of growth cone advance. CALI of dynamitin in vitro dissociates another dynactin subunit, p150Glued, from dynamitin. These results indicate that dynactin, especially the interaction between dynamitin and p150Glued, plays an essential role in growth cone advance.

本文言語English
ページ(範囲)418-422
ページ数5
ジャーナルBiochemical and Biophysical Research Communications
372
3
DOI
出版ステータスPublished - 2008 8 1
外部発表はい

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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