Dynamic subcellular localization of aquaporin-7 in white adipocytes

Takayuki Miyauchi, Hiroyuki Yamamoto, Yoichiro Abe, Go J. Yoshida, Aleksandra Rojek, Eisei Sohara, Shinichi Uchida, Søren Nielsen, Masato Yasui

研究成果: Article査読

19 被引用数 (Scopus)

抄録

Aquaporin-7 (AQP7) is expressed in adipose tissue, permeated by water and glycerol, and is involved in lipid metabolism. AQP7-null mice develop obesity, insulin resistance, and adipocyte hypertrophy. Here, we show that AQP7 is expressed in adipocyte plasma membranes, and is re-localized to intracellular membranes in response to catecholamine in mouse white adipose tissue. We found that internalization of AQP7 was induced by PKA activation and comparative gene identification 58 (CGI-58). This relocation was confirmed by functional studies in 3T3-L1 adipocytes. Collectively, these results suggest that AQP7 makes several contributions to adipocyte metabolism, in both cortical and intracellular membranes.

本文言語English
ページ(範囲)608-614
ページ数7
ジャーナルFEBS Letters
589
5
DOI
出版ステータスPublished - 2015 2 27

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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