Dysbiosis and Staphyloccus aureus Colonization Drives Inflammation in Atopic Dermatitis

Tetsuro Kobayashi, Martin Glatz, Keisuke Horiuchi, Hiroshi Kawasaki, Haruhiko Akiyama, Daniel H. Kaplan, Heidi H. Kong, Masayuki Amagai, Keisuke Nagao

研究成果: Article査読

217 被引用数 (Scopus)

抄録

Staphyloccus aureus skin colonization is universal inatopic dermatitis and common in cancer patients treated with epidermal growth factor receptor inhibitors. However, the causal relationship of dysbiosis and eczema has yet to be clarified. Herein, we demonstrate that Adam17fl/flSox9-Cre mice, generated to model ADAM17-deficiency in human, developed eczematous dermatitis with naturally occurring dysbiosis, similar to that observed inatopic dermatitis. Corynebacterium mastitidis, S.aureus, and Corynebacterium bovis sequentially emerged during the onset of eczematous dermatitis, and antibiotics specific for these bacterial species almost completely reversed dysbiosis and eliminated skin inflammation. Whereas S.aureus prominently drove eczema formation, C.bovis induced robust Thelper 2 cell responses. Langerhans cells were required for eliciting immune responses against S.aureus inoculation. These results characterize differential contributions of dysbiotic flora during eczema formation, and highlight the microbiota-host immunity axis as a possible target for future therapeutics in eczematous dermatitis.

本文言語English
ページ(範囲)756-766
ページ数11
ジャーナルImmunity
42
4
DOI
出版ステータスPublished - 2015 4 21

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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