Dysregulated balance of retinoid-related orphan receptor γt-dependent innate lymphoid cells is involved in the pathogenesis of chronic DSS-induced colitis

Kayoko Kimura, Takanori Kanai, Atsushi Hayashi, Yohei Mikami, Tomohisa Sujino, Shinta Mizuno, Tango Handa, Katsuyoshi Matsuoka, Tadakazu Hisamatsu, Toshiro Sato, Toshifumi Hibi

研究成果: Article査読

13 被引用数 (Scopus)

抄録

Retinoid-related orphan receptor (ROR) γt-expressing and IL-22-producing NKp46+ innate lymphoid (ILC22) cells reside in the lamina propria of the intestine in mice, suggesting that ILC22 cells contribute to host defense during intestinal damage in models of colitis in mice. Nevertheless, another set of pathological interferon (IFN)-γ and/or IL-17A-producing innate lymphoid cells (ILC1 and ICL17) may participate in the pathogenesis in different models of colitis. We here showed that RORγt+IL-22+ ILC22 cells were localized in Thy-1highSCA-1high and/or Thy-1highSCA-1low subpopulations of the intestine in normal and dextran sodium sulfate (DSS)-induced colitic RORγt-sufficient Rag-2-/- mice. RORγt-deficient Rag-2-/- mice developed more severe DSS-induced colitis accompanied with lower expression of REG3β and REG3γ in the colon, but with a lower ratio and absolute number of IFN-γ-producing ILC1 cells as compared to control RORγt-sufficient Rag-2-/- mice. Collectively, not only the presence of ILC22 cells but also the balance of protective and pathogenic ILCs may be involved in the prevention of colitis.

本文言語English
ページ(範囲)694-700
ページ数7
ジャーナルBiochemical and Biophysical Research Communications
427
4
DOI
出版ステータスPublished - 2012 11 2

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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