Dysregulation of the Synaptic Cytoskeleton in the PFC Drives Neural Circuit Pathology, Leading to Social Dysfunction

Il Hwan Kim, Namsoo Kim, Sunwhi Kim, Koji Toda, Christina M. Catavero, Jamie L. Courtland, Henry H. Yin, Scott H. Soderling

研究成果: Article査読

7 被引用数 (Scopus)

抄録

Kim et al. exploit circuit-selective gene manipulation approaches in vivo to specifically knock out ArpC3 in the PFC-BLA circuit and find disrupted neuronal activities in the circuit, leading to abnormal social behavior. Optogenetic PFC-BLA circuit activation disrupts sociability of normal mice, while optogenetic circuit silencing rescues the abnormal sociability in the circuit knockout mice.

本文言語English
論文番号107965
ジャーナルCell Reports
32
4
DOI
出版ステータスPublished - 2020 7月 28
外部発表はい

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)

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