@article{907ec8e832cb403e8e259e84a4660ab7,
title = "Dysregulation of the Synaptic Cytoskeleton in the PFC Drives Neural Circuit Pathology, Leading to Social Dysfunction",
abstract = "Kim et al. exploit circuit-selective gene manipulation approaches in vivo to specifically knock out ArpC3 in the PFC-BLA circuit and find disrupted neuronal activities in the circuit, leading to abnormal social behavior. Optogenetic PFC-BLA circuit activation disrupts sociability of normal mice, while optogenetic circuit silencing rescues the abnormal sociability in the circuit knockout mice.",
keywords = "Arp2/3, ArpC3, basolateral amygdala, circuit pathology, cytoskeleton, neural circuit, prefrontal cortex, schizophrenia, social behavior",
author = "Kim, {Il Hwan} and Namsoo Kim and Sunwhi Kim and Koji Toda and Catavero, {Christina M.} and Courtland, {Jamie L.} and Yin, {Henry H.} and Soderling, {Scott H.}",
note = "Funding Information: We thank Drs. William Wetsel, Stephen Lisberger, Nicole Calakos, and Richard Mooney for their critical reading and comments; Drs. Ramona Rodriguiz and Erin Spence for behavioral technical support; Jonnathan Singh Alvarado and Shanna Resendez (Inscopix) for technical support and advice on head-mounted microscopy; and Michael Richardson for video editing support. This work was supported by National Institutes of Health ( NIH ) grant MH117429 and National Alliance for Research on Schizophrenia and Depression ( NARSAD ) Young Investigator grant 25163 (I.H.K.), NIH grants MH103374 and NS059957 (S.H.S.), and NIH grant MH112883 (H.H.Y.). Publisher Copyright: {\textcopyright} 2020 The Authors",
year = "2020",
month = jul,
day = "28",
doi = "10.1016/j.celrep.2020.107965",
language = "English",
volume = "32",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "4",
}