Early intervention with adalimumab may contribute to favorable clinical efficacy in patients with Crohn's disease

Jun Miyoshi, Tadakazu Hisamatsu, Katsuyoshi Matsuoka, Makoto Naganuma, Yuriko Maruyama, Kazuaki Yoneno, Kiyoto Mori, Hiroki Kiyohara, Kosaku Nanki, Susumu Okamoto, Tomoharu Yajima, Yasushi Iwao, Haruhiko Ogata, Toshifumi Hibi, Takanori Kanai

研究成果: Article査読

15 被引用数 (Scopus)

抄録

Background: We evaluated the clinical efficacy of adalimumab (ADA) for Crohn's disease (CD) and analyzed predictive factors for clinical remission and long-term prognosis. Methods: We retrospectively reviewed the medical records of 45 patients treated with ADA for CD at Keio University Hospital between October 2010 and March 2014. Clinical remission was defined as a Harvey-Bradshaw index of ≤ 4. Results: Twenty-eight of 45 patients (62.2%) achieved clinical remission at week 4. Among these 28 patients, 18 patients (64.3%) maintained clinical remission at week 26, and among these, 16 patients (88.9%) maintained clinical remission at week 52. Absence of a history of bowel resection and absence of prior anti-tumor necrosis factor (anti-TNF) therapy were significant predictive factors for clinical remission at week 4 upon multivariate logistic regression analyses. Younger age and a disease duration of ≤ 3 years correlated with clinical remission at week 26 upon univariate analyses. Patients without a history of bowel resection showed significantly better long-term prognosis than those with a history of bowel resection (p = 0.01). None of the patients contracted a serious infectious disease. Conclusions: Younger age, shorter duration of disease, being naive to anti-TNF antagonists, and absence of a history of bowel resection were associated with the efficacy of ADA in CD patients.

本文言語English
ページ(範囲)130-136
ページ数7
ジャーナルDigestion
90
2
DOI
出版ステータスPublished - 2014 11 7

ASJC Scopus subject areas

  • 消化器病学

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