EBV-positive Burkitt lymphoma as a late-onset posttransplantion lymphoproliferative disorder after allogeneic stem cell transplantation

Naohiro Sekiguchi, Junko Nishimoto, Ryuji Tanosaki, Nobuko Kubota, Yukiko Yokota, Yukio Kobayashi, Takashi Watanabe, Masahiro Kami, Yoichi Takaue, Yoshihiro Matsuno, Kensei Tobinai

研究成果: Article

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Posttransplantation lymphoproliferative disorder (PTLD) is one of the well-recognized complications after allogeneic stem cell transplantation (SCT). It generally occurs early after SCT, and only a few reports of late-onset cases are available. We report a 58-year-old male patient who developed lymphoma 4 years after allogeneic SCT for chronic myeloid leukemia. The presence of c-myc translocation and Epstein-Barr virus-encoded RNA in the lymphoma cells, without rearrangement of the 3′-bcr region, confirmed the histopathologic diagnosis of Burkitt lymphoma. DNA chimerism analysis revealed that the lymphoma cells were of donor origin. The patient achieved complete response with intensive chemotherapy. To our knowledge, this is the first report of Burkitt lymphoma as a PTLD occurring after allogeneic SCT.

元の言語English
ページ(範囲)387-389
ページ数3
ジャーナルInternational journal of hematology
79
発行部数4
DOI
出版物ステータスPublished - 2004 5
外部発表Yes

ASJC Scopus subject areas

  • Hematology

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    Sekiguchi, N., Nishimoto, J., Tanosaki, R., Kubota, N., Yokota, Y., Kobayashi, Y., Watanabe, T., Kami, M., Takaue, Y., Matsuno, Y., & Tobinai, K. (2004). EBV-positive Burkitt lymphoma as a late-onset posttransplantion lymphoproliferative disorder after allogeneic stem cell transplantation. International journal of hematology, 79(4), 387-389. https://doi.org/10.1532/IJH97.03175