ECM-Based Gradient Generator for Tunable Surface Environment by Interstitial Flow

Azusa Shimizu, Wei H. Goh, Rahul B. Karyappa, Michinao Hashiomoto, Hiroaki Onoe

研究成果: Conference contribution

抄録

We present an extracellular matrix(ECM)-based microfluidic device that creates a spatial chemical gradient by interstitial flow. Cells located on surfaces of ECM, such as vascular and skin tissues, are influenced by external factors, including interstitial flows, but few methods have been available to recapitulate such conditions. To address this gap, we developed a microfluidic device that can expose cells cultured on the surface of ECM to a continuous concentration gradient created by the interstitial flow. With a 3D printed water-soluble sacrificial mold, we readily fabricated ECM-based microfluidic devices embedding micromixers and a gradient generator. ECM mimicked the permeability of in vivo environments. Our device will serve as a platform to study cellular phenomena occurring on the surface of ECM, such as vascularization and migration of cancer cells.

本文言語English
ホスト出版物のタイトル33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020
出版社Institute of Electrical and Electronics Engineers Inc.
ページ122-124
ページ数3
ISBN(電子版)9781728135809
DOI
出版ステータスPublished - 2020 1
イベント33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020 - Vancouver, Canada
継続期間: 2020 1 182020 1 22

出版物シリーズ

名前Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
2020-January
ISSN(印刷版)1084-6999

Conference

Conference33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020
CountryCanada
CityVancouver
Period20/1/1820/1/22

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Mechanical Engineering
  • Electrical and Electronic Engineering

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