Ectopic expression of epidermal antigens renders the lung a target organ in paraneoplastic pemphigus

Tsuyoshi Hata, Shuhei Nishimoto, Keisuke Nagao, Hayato Takahashi, Kazue Yoshida, Manabu Ohyama, Taketo Yamada, Koichiro Asano, Masayuki Amagai

研究成果: Article査読

33 被引用数 (Scopus)

抄録

Paraneoplastic pemphigus (PNP) is an autoimmune disease of the skin and mucous membranes that can involve fatal lung complications. IgG autoantibodies target the cell adhesion molecules desmoglein (Dsg)3 and plakins, but the nature and targets of infiltrating T cells are poorly characterized. Moreover, the lung involvement in this skin Ag-specific autoimmune condition represents a paradox. To mimic autoimmunity in PNP, we grafted wild-type skin onto Dsg3-/- mice, which resulted in graft rejection and generation of anti-Dsg3 IgG and Dsg3-specific T cells. Transfer of splenocytes from these mice into Rag2-/- mice induced a combination of suprabasilar acantholysis and interface dermatitis, a histology unique to PNP. Furthermore, the recipient mice showed prominent bronchial inflammation of CD4+ and CD8+ T cells with high mortality. Intriguingly, ectopic Dsg3 expression was observed in the lungs of PNP mice, mirroring the observation that squamous metaplasia is often found in the lungs of PNP patients. Dsg3 and other epidermal Ags were ectopically expressed in the lungs after pulmonary injuries by naphthalene, which was sufficient for recruitment of Dsg3-specific CD4+ T cells. These findings demonstrate that squamous metaplasia after pulmonary epithelial injury may play a crucial role in redirecting the skin-specific autoimmune reaction to the lungs in PNP.

本文言語English
ページ(範囲)83-90
ページ数8
ジャーナルJournal of Immunology
191
1
DOI
出版ステータスPublished - 2013 7月 1

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学

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