Studies were designed to explore the role of vitamin E nutritional status in regulating the synthesis of α-tocopherol transfer protein (αTTP) in rat liver. In vitamin E-replete rats, expression of this protein and its specific messenger RNA (mRNA) was decreased by about 300% compared with rats with normal vitamin E levels. In vitamin E-depleted rats, the αTTP-specific mRNA level increased to about 150% of that in the normal vitamin E group. However, protein expression remained constant. These findings indicate that the synthesis of αTTP can be regulated by the vitamin E nutritional status.
|ジャーナル||Free Radical Research|
|出版ステータス||Published - 1998 4 23|
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