Effect of anti-attention-deficit hyperactivity disorder (ADHD) medication on clinical seizures and sleep EEG: A retrospective study of Japanese children with ADHD

Hisako Yamamoto, Eiji Nakagawa, Yousuke Kita, Yoshimi Kaga, Masumi Inagaki

研究成果: Article査読

抄録

Aims: Patients with attention-deficit hyperactivity disorder (ADHD) often exhibit basic or paroxysmal wave abnormalities on electroencephalography (EEG). Methylphenidate (MPH), an anti-ADHD stimulant, has been reported to lower the seizure threshold. However, there have been no reports comparing EEG changes before and after administration of the central nervous system (CNS) stimulant MPH, or atomoxetine (ATX) hydrochloride, a non-CNS stimulant. In this study, we investigated changes in sleep EEG before and after the administration of ADHD treatment drugs. Method: With the approval of the ethics committee, the medical records of 28 children with ADHD (23 men and 5 women) who gave consent were retrospectively investigated. The appearance of sudden abnormal waves during a 10-minute sleep EEG recording was measured in 0.1-second units, and the duration of these waves was calculated as the paroxysmal index (PI). Results: Paroxysmal index did not differ significantly between patients who received MPH and those who received ATX. In addition, there were no exacerbations of clinical seizures. Conclusion: It was concluded that ADHD medications do not have an adverse effect on epileptic seizures or abnormal sleep EEGs.

本文言語English
ページ(範囲)511-521
ページ数11
ジャーナルNeuropsychopharmacology Reports
41
4
DOI
出版ステータスPublished - 2021 12月
外部発表はい

ASJC Scopus subject areas

  • 臨床心理学
  • 薬理学
  • 精神医学および精神衛生
  • 薬理学(医学)

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