Effect of caloric intake on western-style diet-induced intestinal tumors in a mouse model for hereditary colon cancer

Osamu Itano, Kunhua Fan, Kan Yang, Keiich Suzuki, Fred Quimby, Zhiqian Dong, Bo Jin, Winfried Edelmann, Martin Lipkin

研究成果: Article

2 引用 (Scopus)

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Increased caloric intake has been associated with increased risk for cancer of the large intestine. We studied caloric intake effect on tumor formation in Apc1638 N/+ mice, a preclinical model for human familial adenomatous polyposis. Mice were fed a controlled AIN-76A diet or a new Western-style diet (NWD). Intestinal tumor development was evaluated after 6 mo of feeding 1) AIN-76A diet (fed ad libitum) vs. AIN-76A (caloric intake reduced 30%); 2) NWD (fed ad libitum) vs. NWD (caloric intake reduced 30%); and 3) AIN-76A (fed ad libitum) vs. NWD (paired-fed with NWD providing equal caloric intakes to AIN-76A). Intestinal tumor incidences were 78-100% with intergroup variation P > 0.05; however, tumor multiplicity responded differently to dietary treatment: 1) Tumor multiplicity was unchanged after AIN-76A (caloric intake reduced 30% vs. mice fed AIN-76A ad libitum); 2) tumor multiplicity was unchanged after NWD (caloric intake reduced 30% vs. NWD ad libitum); and 3) tumor multiplicity increased 130% after NWD was paired-fed with the same caloric intake as mice fed AIN-76A ad libitum (P < 0.05). Body weights showed no association with tumor development. Findings indicated modified nutrients in NWD were mainly responsible for increased tumors in mice fed NWD vs. AIN-76A in this preclinical mouse model for human FAP.

元の言語English
ページ(範囲)401-408
ページ数8
ジャーナルNutrition and Cancer
64
発行部数3
DOI
出版物ステータスPublished - 2012 4 1
外部発表Yes

    フィンガープリント

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Oncology
  • Cancer Research

これを引用

Itano, O., Fan, K., Yang, K., Suzuki, K., Quimby, F., Dong, Z., Jin, B., Edelmann, W., & Lipkin, M. (2012). Effect of caloric intake on western-style diet-induced intestinal tumors in a mouse model for hereditary colon cancer. Nutrition and Cancer, 64(3), 401-408. https://doi.org/10.1080/01635581.2012.660672