Effect of conformation of the substrate on enzymatic eecarboxylation of α-Arylmalonic Acid

Kenji Miyamoto, Hiromichi Ohta, Yoshihiro Osamura

研究成果: Article査読

14 被引用数 (Scopus)

抄録

The configuration and conformation of a compound are critical factors that determine whether it can be accepted by an enzyme is a substrate or not. We have examined enzyme-catalyzed decarboxylation of some α-substituted malonic acids and proposed that the syn-periplanar conformation is required for the substrates to be bound to the active site of the enzyme. Theoretical calculation of potential energy surfaces also supports the conclusion from experimental results.

本文言語English
ページ(範囲)469-475
ページ数7
ジャーナルBioorganic and Medicinal Chemistry
2
6
DOI
出版ステータスPublished - 1994 6

ASJC Scopus subject areas

  • 生化学
  • 分子医療
  • 分子生物学
  • 薬科学
  • 創薬
  • 臨床生化学
  • 有機化学

フィンガープリント

「Effect of conformation of the substrate on enzymatic eecarboxylation of α-Arylmalonic Acid」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル