Effect of dithiothreitol on angiotensin II receptor type II in rat ovarian cultured granulosa cells

Junji Ohnishi, Masami Tanaka, Mitsuhide Naruse, Satoshi Usuki, Kazuo Murakami, Hitoshi Miyazaki

研究成果: Article査読

10 被引用数 (Scopus)

抄録

Dithiothreitol markedly increased the ligand binding affinity of angiotensin II (AII) receptor type II (AT2) without affecting its antagonist selectivity in cultured ovarian granulosa cells, demonstrating that this AT2 is of the dithiothreitol-sensitive type. Dithiothreitol is useful for specifically detecting low levels of the AT2 in the ovary, where it plays roles that are probably related to atresia.

本文言語English
ページ(範囲)286-288
ページ数3
ジャーナルBBA - Biomembranes
1192
2
DOI
出版ステータスPublished - 1994 6 22

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 細胞生物学

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