Effect of Estradiol and Ethynylestradiol on Microtubule Distribution in Chinese Hamster V79 Cells

Yoshihiro Sato; Yumiko Sakakibara; Taiko Oda; Eriko Aizu-Yokota; Ken Ichinoseki

doi:10.1248/cpb.40.182

Effect of Estradiol and Ethynylestradiol on Microtubule Distribution in Chinese Hamster V79 Cells

Yoshihiro Sato, Yumiko Sakakibara, Taiko Oda, Eriko Aizu-Yokota, Ken Ichinoseki

薬学科

研究成果: Article › 査読

21 被引用数 (Scopus)

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The effects of estradiol (E₂) and ethynylestradiol (EE₂) on the chromosome number and cellular microtubule architecture of Chinese hamster V79 cells were studied using fluorescent anti-tubulin antibody. Treatment with 20 pM E₂ for 48 h induced only a small amount of tetraploid cells, but the normal microtubule network was disrupted completely by only 3h of treatment. This data reveals that E₂ has higher microtubule-disruptive activity than diethylstilbestrol in V79 cells.

本文言語	English
ページ（範囲）	182-184
ページ数	3
ジャーナル	Chemical and Pharmaceutical Bulletin
巻	40
号	1
DOI	https://doi.org/10.1248/cpb.40.182
出版ステータス	Published - 1992

ASJC Scopus subject areas

化学 (全般)
創薬

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title = "Effect of Estradiol and Ethynylestradiol on Microtubule Distribution in Chinese Hamster V79 Cells",

abstract = "The effects of estradiol (E2) and ethynylestradiol (EE2) on the chromosome number and cellular microtubule architecture of Chinese hamster V79 cells were studied using fluorescent anti-tubulin antibody. Treatment with 20 pM E2 for 48 h induced only a small amount of tetraploid cells, but the normal microtubule network was disrupted completely by only 3h of treatment. This data reveals that E2 has higher microtubule-disruptive activity than diethylstilbestrol in V79 cells.",

keywords = "aneuploidy, chromosome aberration, estradiol, ethynylestradiol, immunofluorescence, microtubule distribution",

author = "Yoshihiro Sato and Yumiko Sakakibara and Taiko Oda and Eriko Aizu-Yokota and Ken Ichinoseki",

year = "1992",

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T1 - Effect of Estradiol and Ethynylestradiol on Microtubule Distribution in Chinese Hamster V79 Cells

AU - Sato, Yoshihiro

AU - Sakakibara, Yumiko

AU - Oda, Taiko

AU - Aizu-Yokota, Eriko

AU - Ichinoseki, Ken

PY - 1992

Y1 - 1992

N2 - The effects of estradiol (E2) and ethynylestradiol (EE2) on the chromosome number and cellular microtubule architecture of Chinese hamster V79 cells were studied using fluorescent anti-tubulin antibody. Treatment with 20 pM E2 for 48 h induced only a small amount of tetraploid cells, but the normal microtubule network was disrupted completely by only 3h of treatment. This data reveals that E2 has higher microtubule-disruptive activity than diethylstilbestrol in V79 cells.

AB - The effects of estradiol (E2) and ethynylestradiol (EE2) on the chromosome number and cellular microtubule architecture of Chinese hamster V79 cells were studied using fluorescent anti-tubulin antibody. Treatment with 20 pM E2 for 48 h induced only a small amount of tetraploid cells, but the normal microtubule network was disrupted completely by only 3h of treatment. This data reveals that E2 has higher microtubule-disruptive activity than diethylstilbestrol in V79 cells.

KW - aneuploidy

KW - chromosome aberration

KW - estradiol

KW - ethynylestradiol

KW - immunofluorescence

KW - microtubule distribution

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Effect of Estradiol and Ethynylestradiol on Microtubule Distribution in Chinese Hamster V79 Cells

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