Effect of Estradiol and Ethynylestradiol on Microtubule Distribution in Chinese Hamster V79 Cells

Yoshihiro Sato, Yumiko Sakakibara, Taiko Oda, Eriko Aizu-Yokota, Ken Ichinoseki

研究成果: Article査読

41 被引用数 (Scopus)

抄録

The effects of estradiol (E2) and ethynylestradiol (EE2) on the chromosome number and cellular microtubule architecture of Chinese hamster V79 cells were studied using fluorescent anti-tubulin antibody. Treatment with 20 pM E2 for 48 h induced only a small amount of tetraploid cells, but the normal microtubule network was disrupted completely by only 3h of treatment. This data reveals that E2 has higher microtubule-disruptive activity than diethylstilbestrol in V79 cells.

本文言語English
ページ(範囲)182-184
ページ数3
ジャーナルChemical and Pharmaceutical Bulletin
40
1
DOI
出版ステータスPublished - 1992

ASJC Scopus subject areas

  • 化学 (全般)
  • 創薬

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