TY - JOUR
T1 - Effect of Goreisan, a Japanese Traditional Medicine, on Cortical Spreading Depolarization in Mice
AU - Iba, Chisato
AU - Unekawa, Miyuki
AU - Izawa, Yoshikane
AU - Nakahara, Jin
AU - Takizawa, Tsubasa
N1 - Funding Information:
This work was supported by study funds from Tsumura & Co. to T.T. and the Keio University Program for the Advancement of Next Generation Research Projects to J.N. The costs of publication of this article were defrayed in part by a research fund provided by the Japanese Headache Society.
Publisher Copyright:
© 2022 by the authors.
PY - 2022/11
Y1 - 2022/11
N2 - Goreisan, a traditional Japanese Kampo medicine, is often used to treat headaches, including migraines; however, the underlying mechanisms remain unknown. Therefore, we investigated whether chronic treatment with Goreisan affects cortical spreading depolarization (CSD) in migraines. CSD susceptibility was assessed in male and female C57BL/6 mice by comparing CSD threshold, propagation velocity, and CSD frequency between animals treated with Goreisan for approximately 3 weeks and the corresponding controls with a potassium-induced CSD model. No significant differences were observed in CSD susceptibility between mice that were chronically treated with Goreisan and the control mice. Additionally, no significant differences were observed in other physiological parameters, including body weight, blood gases, and blood pressure. CSD susceptibility was not affected by chronic treatment with Goreisan, which suggests that the drug treats headaches via mechanisms that do not involve CSD modulation.
AB - Goreisan, a traditional Japanese Kampo medicine, is often used to treat headaches, including migraines; however, the underlying mechanisms remain unknown. Therefore, we investigated whether chronic treatment with Goreisan affects cortical spreading depolarization (CSD) in migraines. CSD susceptibility was assessed in male and female C57BL/6 mice by comparing CSD threshold, propagation velocity, and CSD frequency between animals treated with Goreisan for approximately 3 weeks and the corresponding controls with a potassium-induced CSD model. No significant differences were observed in CSD susceptibility between mice that were chronically treated with Goreisan and the control mice. Additionally, no significant differences were observed in other physiological parameters, including body weight, blood gases, and blood pressure. CSD susceptibility was not affected by chronic treatment with Goreisan, which suggests that the drug treats headaches via mechanisms that do not involve CSD modulation.
KW - Goreisan
KW - Kampo medicine
KW - cortical spreading depolarization
KW - migraine
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U2 - 10.3390/ijms232213803
DO - 10.3390/ijms232213803
M3 - Article
C2 - 36430280
AN - SCOPUS:85142668141
SN - 1661-6596
VL - 23
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 22
M1 - 13803
ER -