Effect of monoenergetic neutron irradiation on the postnatal development of the cochlea in C3H/HeN mice

Yumiko Nitta, Nobukazu Araki, Kohsaku Nitta, Toshihide Harada, Fumiko Ishizaki, Weiping Cheng, Juko Ando

研究成果: Article査読

1 被引用数 (Scopus)

抄録

To investigate the toxic effect of neutrons at energies of approximately 1MeV on the ear, we exposed 7-day-old mice to 1.0 Gy of monoenergetic neutrons (1.026 MeV) or 137Cs gamma rays, and assessed subsequent morphological changes in the inner ear by light and scanning electron microscopy. Monoenergetic neutrons, but not gamma rays, caused acute changes in the ear. The epithelium of the greater epithelial ridge in the organ of Corti had disappeared by 72 hr post-irradiation, as a result of epithelial apoptosis observed 6 hr post-irradiation. Radiation could induce apoptotic cell death of the epithelium of the greater epithelial ridge at 3 or 4 days of age. Protruding structures were detected on the surface of the hair cells by 72 hr post-irradiation. The neutron-irradiation also caused the apoptotic cell death of epithelial cells at the nasal conchae, and subsequent acute otitis media continued until 10 weeks of age.

本文言語English
ページ(範囲)577-582
ページ数6
ジャーナルJournal of Veterinary Medical Science
67
6
DOI
出版ステータスPublished - 2005 6

ASJC Scopus subject areas

  • 獣医学(全般)

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