Effect of nimodipine, a calcium antagonist, on cerebral vasospasm after subarachnoid hemorrhage in cats

K. Tanaka, F. Gotoh, F. Muramatsu, Y. Fukuuchi, H. Okayasu, N. Suzuki, M. Kobari

研究成果: Article査読

36 被引用数 (Scopus)

抄録

Effect of a calcium antagonist, isopropyl-(2-methoxyethyl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5- pyridinedicarboxylate (nimodipine) on the cerebral vasospasm after experimental subarachnoid hemorrhage (SAH) was studied in 10 adult cats. The vasospasm was induced by injection of 0.2-0.3 ml fresh autologous whole blood into the cisterna magna. Diameter of pial vessels was continuously measured by means of the vidicon camera system developed in our laboratory. Intravenous administration of nimodipine (0.1 mg/kg) 20-30 min after SAH resulted in a complete disappearance of the spasm with the reduction of blood pressure. The dilatatory response was more marked in the smaller arteries (< 100 μm) than in the larger ones (≥ 100 μm). Administration of a smaller dose of nimodipine (0.01 mg/kg) also produced dilation of the pial vessels, although the effect was less remarkable in the smaller arteries. These data suggest that nimodipine might be useful in the treatment of the cerebral vasospasm after SAH. The mechanism underlying the action of nimodipine was discussed.

本文言語English
ページ(範囲)1529-1534
ページ数6
ジャーナルArzneimittel-Forschung/Drug Research
32
12
出版ステータスPublished - 1982 12 1

ASJC Scopus subject areas

  • Drug Discovery

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