Effect of rebamipide on H. pylori-associated gastric mucosal injury in Mongolian gerbils

H. Suzuki, M. Mori, A. Kai, M. Suzuki, M. Suematsu, S. Miura, H. Ishii

研究成果: Article査読

7 被引用数 (Scopus)


Helicobacter pylori colonized to gastric mucosa plays an important pathogenic role in gastric mucosal lesions. We previously reported that ethanol pretreatment promotes the extension of H. pylori-associated lesions. The present study was designed to examine the effect of rebamipide, a mucosal protective agent, on H. pylori-associated injury. Male Mongolian gerbils were orally inoculated with H. pylori; 30 min prior to inoculation, 40% ethanol was administered orally to these gerbils (Hp group). Controls were given 40% ethanol with culture medium (control group). Some gerbils in the Hp find control groups were fed rebamipide-containing diets, and the remaining gerbils received laboratory chow diets. H. pylori infection was evaluated by quantitative bacterial culture and histological examination. Although H. pylori was persistently detected and a remarkable mucosal leukocyte infiltration was observed in the Hp groups, the bacteria had disappeared naturally in 67% of the gerbils and mucosal damage was mitigated in the Hp + rebamipide group at four weeks after the inoculation. Collectively, rebamipide might play a role in inhibiting the level of H. pylori colonization and gastric lesion formation in Mongolian gerbils.

ジャーナルDigestive Diseases and Sciences
出版ステータスPublished - 1998 10月 3

ASJC Scopus subject areas

  • 生理学
  • 消化器病学


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