Effect of skin flap ischemia on plasma endothelin-1 levels

K. Matsuzaki

研究成果: Article

14 引用 (Scopus)

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A number of studies have been done relating to vasospasm. Vasospasm within the microvasculature of a flap can be one of the causes of ischemia and nonviability. Endothelin-1 (ET-1), a 21-amino acid polypeptide isolated from vascular endothelium culture media, is reported to be one of the most potent vasoconstrictors known. This experimental study, using a rabbit epigastric island flap, was designed to investigate whether skin flap ischemia influenced plasma ET-1 levels. After the ischemic insult, blood was drawn from the venous effluent of the flaps. Plasma ET-1 levels after 6 hours of ischemia were significantly increased compared with nonischemic controls; they were 29 pM, i.e., almost enough to induce vasoconstriction of arterioles. These results suggest that ET-1 is one of the factors responsible for partial necrosis of the skin flap, which contributes to the genesis of the no-reflow phenomenon.

元の言語English
ページ(範囲)499-503
ページ数5
ジャーナルAnnals of Plastic Surgery
31
発行部数6
DOI
出版物ステータスPublished - 1993 1 1

ASJC Scopus subject areas

  • Surgery

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