Effect of the antioxidant supplement pyrroloquinoline quinone disodium salt (BioPQQ™) on cognitive functions

Yuji Itoh, Kyoko Hine, Hiroshi Miura, Tatsuo Uetake, Masahiko Nakano, Naohiro Takemura, Kaoru Sakatani

研究成果: Conference contribution

22 被引用数 (Scopus)

抄録

Pyrroloquinoline quinone (PQQ) is a quinone compound first identified in 1979. It has been reported that rats fed a PQQ-supplemented diet showed better learning ability than controls, suggesting that PQQ may be useful for improving memory in humans. In the present study, a randomized, placebo-controlled, doubleblinded study to examine the effect of PQQ disodium salt (BioPQQ™) on cognitive functions was conducted with 41 elderly healthy subjects. Subjects were orally given 20 mg of BioPQQ™ per day or placebo, for 12 weeks. For cognitive functions, selective attention by the Stroop and reverse Stroop test, and visualspatial cognitive function by the laptop tablet Touch M, were evaluated. In the Stroop test, the change of Stroop interference ratios (SIs) for the PQQ group was significantly smaller than for the placebo group. In the Touch M test, the stratification analyses dividing each group into two groups showed that only in the lower group of the PQQ group (initial score<70), did the score significantly increase. Measurements of physiological parameters indicated no abnormal blood or urinary adverse events, nor adverse internal or physical examination findings at any point in the study. The preliminary experiment using near-infrared spectrometry (NIRS) suggests that cerebral blood flow in the prefrontal cortex was increased by the administration of PQQ. The results suggest that PQQ can prevent reduction of brain function in aged persons, especially in attention and working memory.

本文言語English
ホスト出版物のタイトルOxygen Transport to Tissue XXXVII
編集者Clare E. Elwell, Terence S. Leung, David K. Harrison
出版社Springer New York LLC
ページ319-325
ページ数7
ISBN(印刷版)9781493930227
DOI
出版ステータスPublished - 2016
イベント42nd Annual Meeting of International Society on Oxygen Transport to Tissue - London, United Kingdom
継続期間: 2014 6月 282014 7月 3

出版物シリーズ

名前Advances in Experimental Medicine and Biology
876
ISSN(印刷版)0065-2598
ISSN(電子版)2214-8019

Other

Other42nd Annual Meeting of International Society on Oxygen Transport to Tissue
国/地域United Kingdom
CityLondon
Period14/6/2814/7/3

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)

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