Effects of 2′-demethoxy-2′-propoxygriseofulvin on microtubule distribution in Chinese hamster V79 cells

Taiko Oda

研究成果: Article査読

7 被引用数 (Scopus)

抄録

Griseofulvin may combine with tubulin as a component of microtubules and, at high doses, inhibits microtubule formation in mammalian cells. In this study, the author examined the effects of three various 2′-substitutive derivatives of griseofulvin on microtubule distribution in Chinese hamster V79 cells. The results showed that 2′-demethoxy-2′propoxygriseofulvin was the strongest inhibitor of a normal cytoplasmic microtubule network, unlike findings in previous in-vitro studies.

本文言語English
ページ(範囲)114-116
ページ数3
ジャーナルJournal of Antibiotics
59
2
DOI
出版ステータスPublished - 2006 2

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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