Effects of 2-mercaptopropionylglycine on the development of x-ray-induced cataract in rats

Shizuko Kobayashi, Minako Kasuya, Yasuo Ishii, Makoto Takehana, Kazuo Sakai, Norio Suzuki, Motokazu Itoi

研究成果: Article査読

11 被引用数 (Scopus)

抄録

The effect of 2-mercaptopropionylglycine on the development of cataract induced by a single dose of X-ray (10 Gy) was investigated in rats. Intraperitoneal injection of 20 mg/kg, three times weekly starting 1 day after irradiation delayed the development of X-ray-induced cataracts significantly. The amounts of non-protein SH groups, malondialdehyde and the Na+/K+ ratio, in the lenses of rats post-treated with the drug were significantly maintained at normal levels even at 27 weeks after irradiation. On the other hand, a single administration of 250 mg/kg of the compound, 30 min prior to irradiation had no effect on cataract progression induced by X-ray.

本文言語English
ページ(範囲)1099-1103
ページ数5
ジャーナルCurrent Eye Research
11
11
DOI
出版ステータスPublished - 1992
外部発表はい

ASJC Scopus subject areas

  • 眼科学
  • 感覚系
  • 細胞および分子神経科学

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